The Early 35 kDa protein, or P35 in short, is a baculoviral protein that inhibits apoptosis in the cells infected by the virus. Although baculoviruses infect only invertebrates in nature, ectopic expression of P35 in vertebrate animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism. P35 has been shown to be a caspase inhibitor with a very wide spectrum of activity both in regard to inhibited caspase types and to species in which the mechanism is conserved.
^Fisher AJ, Cruz W, Zoog SJ, Schneider CL, Friesen PD (April 1999). "Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition". The EMBO Journal. 18 (8): 2031–9. doi:10.1093/emboj/18.8.2031. PMC 1171287. PMID 10205157.
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