Pregnancy zone protein (PZP), also known as the pregnancy-associated α2-glycoprotein (α2-PAG or PAα2G),[5] is a protein which in humans is encoded by the PZP gene on chromosome 12.[6] PZP is part of the alpha-2 globulin family of proteins.[7] It is often associated with pregnancy, during which it can be the most abundant among the plasma proteins.[8] PZP is believed to play a role in immune-regulation during pregnancy, however many aspects of its mechanism, function and structure are yet to be determined.[9][10] Recent research has largely focused on determining how dysregulated PZP levels can act as a markers of various diseases.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000126838 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030359 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference pmid2664738 was invoked but never defined (see the help page).
^"Entrez Gene: PZP pregnancy-zone protein".
^Wong SG, Dessen A (2014). "Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity". Nature Communications. 5: 4917. doi:10.1038/ncomms5917
^Chiabrando GA, Vides MA, Sanchez MC (2002). “Differential binding properties of human pregnancy zone protein– and a2-macroglobulin–proteinase complexes to low-density lipoprotein receptor-related protein”. Archives of Biochemistry and Biophysics.398(1): 73–78. doi:10.1006/abbi.2001.2659
^Oh JW, Kim SK, Cho K-C, Kim M-S, Suh CS, Lee JR, Kim KP (2017). “Proteomic analysis of human follicular fluid in poor ovarian responders during in vitro fertilization”.Proteomics.17(6). doi:10.1002/pmic.201600333
^Charkoftaki G, Chen Y, Han M, Sandoval M, Yu X, Zhao H, Orlicky DJ, Thompson DC, Vasiliou V
(2017). “Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function”. Chemico-Biological Interactions.276: 15-22. doi:10.1016/j.cbi.2017.02.013
^do Nascimento de Oliveira V, Lima-Neto ABM, van Tilburg MF, de Oliveira Monteiro-Moreira AC, Duarte Pinto Lobo M, Rondina D, Fernandes VO, Montenegro APDR, Montenegro RM Júnior, Guedes MIF (2018) “Proteomic analysis to identify candidate biomarkers associated with type 1 diabetes”. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.11: 289-301. doi:10.2147/DMSO.S162008
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