For the Heckler & Koch semi-automatic handgun, see HK VP40.
VP40
VP40 matrix protein hexamer, Ebola virus
Identifiers
Symbol
VP40
Pfam
PF07447
InterPro
IPR008986
SCOP2
1h2c / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, VP40 is the name of a viral matrix protein. Most commonly, it is found in the Ebola virus (EBOV),[1] a type of non-segmented, negative-strand RNA virus. Ebola virus causes a severe and often fatal haemorrhagic fever in humans, known as Ebola virus disease. The virus matrix protein VP40 is a major structural protein that plays a central role in virus assembly and budding at the plasma membrane of infected cells. VP40 proteins work by associating with cellular membranes, interacting with the cytoplasmic tails of glycoproteins and binding to the ribonucleoprotein complex.[citation needed]
^Dessen, Andréa; Volchkov, Viktor; Dolnik, Olga; Klenk, Hans-Dieter; Weissenhorn, Winfried (2000-08-15). "Crystal structure of the matrix protein VP40 from Ebola virus". The EMBO Journal. 19 (16): 4228–4236. doi:10.1093/emboj/19.16.4228. ISSN 0261-4189. PMC 302032. PMID 10944105.
In molecular biology, VP40 is the name of a viral matrix protein. Most commonly, it is found in the Ebola virus (EBOV), a type of non-segmented, negative-strand...
approximately 19 kbp long and contain seven genes in the order 3'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR. Like all filoviruses, marburgvirions are filamentous...
genomes. Ebolavirus genomes contain seven genes including 3'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR. The genomes of the five different ebolaviruses (BDBV...
that include: NP (nucleoprotein), VP35 (part of the polymerase complex), VP40 (matrix protein), GP (glycoprotein spike), VP30 (transcription activator)...
gene overlaps its genome contains seven genes in the order 3'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR its VP24 gene is not homologous to genes of other mononegaviruses...
endemic in Sudan and/or Uganda it has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L) it has a genomic sequence different from Ebola virus by...
Neumann, Gabriele; Lukashevich, Igor; Kawaoka, Y (2001-06-01). "Ebola virus vp40-induced particle formation and association with the lipid bilayer". J Virol...
EN, Stewart RA, Cai Y, Yu S, et al. (December 2020). "A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical...
approximately 19 kb long and contains seven genes in the order 3'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR. In contrast to ebolaviruses and Marburgviruses, which...
that eVP24 function can overlap with that of two other viral proteins; eVP40 matrix protein which functions in virus budding, and eVP35 which is also...
if: it is endemic in Uganda it has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L) it has a genomic sequence different from Ebola virus by...
rather than on the cell surface. Later, she showed that the Ebola virus VP40 matrix protein can fold into multiple distinct structures. Her laboratory...
proteins (for example, by UL56 from Herpes simplex virus 2, or by protein VP40 from Ebola virus. Such infection aids viruses in taking over the ESCRT pathway...
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