A microprotein (miP) is a small protein encoded from a small open reading frame (smORF).[1] They are a class of protein with a single protein domain that are related to multidomain proteins.[2] Microproteins regulate larger multidomain proteins at the post-translational level.[3] Microproteins are analogous to microRNAs (miRNAs) and heterodimerize with their targets causing dominant and negative effects. [4] In animals and plants, microproteins have been found to greatly influence biological processes.[2] Because of microproteins' dominant effects on their targets, microproteins are currently being studied for potential applications in biotechnology.[2]
^"The Dark Matter of the Human Proteome". The Scientist Magazine®. Retrieved 2019-04-25.
^ abcBhati, Kaushal Kumar; Blaakmeer, Anko; Paredes, Esther Botterweg; Dolde, Ulla; Eguen, Tenai; Hong, Shin-Young; Rodrigues, Vandasue; Straub, Daniel; Sun, Bin (2018-04-18). "Approaches to identify and characterize microProteins and their potential uses in biotechnology". Cellular and Molecular Life Sciences. 75 (14): 2529–2536. doi:10.1007/s00018-018-2818-8. ISSN 1420-682X. PMC 6003976. PMID 29670998.
^Staudt, Annica-Carolin; Wenkel, Stephan (2010-12-10). "Regulation of protein function by 'microProteins'". EMBO Reports. 12 (1): 35–42. doi:10.1038/embor.2010.196. ISSN 1469-221X. PMC 3024132. PMID 21151039.
^Eguen, T; Straub, D; Graeff, M; Wenkel, S (August 2015). "MicroProteins: small size-big impact". Trends in Plant Science. 20 (8): 477–482. doi:10.1016/j.tplants.2015.05.011. PMID 26115780.
A microprotein (miP) is a small protein encoded from a small open reading frame (smORF). They are a class of protein with a single protein domain that...
Mitochondrial intermediate peptidase, an enzyme MIP (gene), a gene in humans Microprotein, a small protein encoded from small open reading frames Mipcom, a TV...
Duggan, Kate M.; McLysaght, Aoife (2022). "De novo birth of functional microproteins in the human lineage". Cell Reports. 41 (12): 111808. doi:10.1016/j...
National Rail station code ZPR The LITTLE ZIPPER (ZPR) protein, the first microprotein discovered in plants ZPR Media Group, a media company in Poland Zero...
S2CID 28916747. Grubb A, Löfberg H (May 1982). "Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis". Proceedings...
Kate M.; McLysaght, Aoife (2022-12-20). "De novo birth of functional microproteins in the human lineage". Cell Reports. 41 (12): 111808. doi:10.1016/j...
PMID 119302. Grubb, A.; Löfberg, H. (1982). "Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis". Proceedings...
crystallization screen. Crystallization of racemates of disulfide-containing microprotein molecules was used to determine the structure of trypsin inhibitor SFTI-1...
S2CID 27976400. Grubb A, Löfberg H (1982). "Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis". Proc. Natl...
Micropeptides (also referred to as microproteins) are polypeptides with a length of less than 100-150 amino acids that are encoded by short open reading...
H, Bernkop-Schnürch A (April 2006). "The potential of cystine-knot microproteins as novel pharmacophoric scaffolds in oral peptide drug delivery". Journal...
Karlseder’s work on DNA repair pathway choice led to the discovery of the microprotein CYREN, which inhibits error prone non-homologous end-joining during S...
Global Information