Attention deficit hyperactivity disorder information
Neurodevelopmental disorder
"Attention Deficit" redirects here. For the album, see Attention Deficit (album).
"ADD", "ADHD", and "Hyperactive" redirect here. For other uses, see ADD (disambiguation), ADHD (disambiguation), and Hyperactive (disambiguation).
Medical condition
Attention deficit hyperactivity disorder
People with ADHD struggle more than others to sustain their attention on some tasks (such as schoolwork), but may maintain an unusually intense level of attention for tasks they find immediately rewarding or interesting.
Specialty
Psychiatry
pediatrics
Symptoms
Inattention
carelessness
hyperactivity
executive dysfunction
disinhibition
emotional dysregulation
impulsivity
impaired working memory
Usual onset
Typically at least some ADHD symptoms and impairments onset during the developmental period. Exceptions include if they were compensated for (e.g., by a high IQ or structured environment) or if the individual clearly suffered a neurologically compromising event.
Causes
Genetic (inherited, de novo) and to a lesser extent, environmental factors (exposure to biohazards during pregnancy, traumatic brain injury)
Diagnostic method
Based on symptoms after other possible causes have been ruled out
Differential diagnosis
Individual without ADHD
symptomatic but unimpaired
bipolar disorder
cognitive disengagement syndrome
conduct disorder
major depressive disorder
autism spectrum disorder
oppositional defiant disorder
learning disorder
intellectual disability
anxiety disorder[1]
borderline personality disorder
fetal alcohol spectrum disorder
Treatment
Psychotherapy
lifestyle changes
medication
Medication
CNS stimulants (methylphenidate, amphetamine)
non-stimulants (atomoxetine, viloxazine)
alpha-2a agonists (guanfacine XR, clonidine XR)
Frequency
0.8–1.5% (2019, using DSM-IV-TR and ICD-10)[2]
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by executive dysfunction occasioning symptoms of inattention, hyperactivity, impulsivity and emotional dysregulation that are excessive and pervasive, impairing in multiple contexts, and otherwise age-inappropriate.[8]
ADHD symptoms arise from executive dysfunction,[17] and emotional dysregulation is often considered a core symptom.[21] Difficulties with self-regulation such as time management, inhibition and sustained attention may result in poor academic performance, unemployment and numerous health risks,[22] collectively predisposing to a diminished quality of life[23] and a direct average reduction in life expectancy of 13 years.[24][25] ADHD is associated with other neurodevelopmental and mental disorders as well as some non-psychiatric disorders, which can cause additional impairment, especially in modern society.[26]
Although people with ADHD struggle to persist on tasks with temporally delayed consequences, they may be able to maintain an unusually prolonged level of attention for tasks they do find intrinsically interesting or immediately rewarding;[27][16] this is known as hyperfocus (more colloquially)[28] or perseverative responding.[29] This is a mental state in which a person is completely absorbed in a task to the point of apparently ignoring or "tuning out" everything else, often with difficulty disengaging[27][30] and can be related to risks such as for internet addiction[31] and types of offending behaviour.[32]
ADHD represents the extreme lower end of the continuous dimensional trait (bell curve) of executive functioning and self-regulation, which is supported by twin, brain imaging and molecular genetic studies.[33][12][34][16][35][36][37]
The precise causes of ADHD are unknown in the majority of cases.[38][39] For most people with ADHD, many genetic and environmental risk factors accumulate to cause the disorder.[40] The environmental risks for ADHD most often exert their influence in the prenatal period.[7] However, in rare cases a single event might cause ADHD such as traumatic brain injury,[41][42][43][44] exposure to biohazards during pregnancy,[7] a major genetic mutation[45] or extreme environmental deprivation early in life.[46] There is no biologically distinct adult onset ADHD except for when ADHD occurs after traumatic brain injury.[47][42][48]
^Young K (9 February 2017). "Anxiety or ADHD? Why They Sometimes Look the Same and How to Tell the Difference". Hey Sigmund. Archived from the original on 26 January 2023. Retrieved 27 January 2023.
^Cite error: The named reference GBD2019 was invoked but never defined (see the help page).
^Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington: American Psychiatric Publishing. 2013. pp. 59–65. ISBN 978-0-89042-555-8.
^Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Washington, D.C.: American Psychiatric Publishing. February 2022. ISBN 978-0-89042-575-6. OCLC 1288423302.
^Cite error: The named reference ICD-11 was invoked but never defined (see the help page).
^Cite error: The named reference Foreman_2006 was invoked but never defined (see the help page).
^ abcFaraone SV, Banaschewski T, Coghill D, Zheng Y, Biederman J, Bellgrove MA, et al. (September 2021). "The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder". Neuroscience and Biobehavioral Reviews. 128. Elsevier BV: 789–818. doi:10.1016/j.neubiorev.2021.01.022. PMC 8328933. PMID 33549739.
^[3][4][5][6][7]
^Pievsky MA, McGrath RE (March 2018). "The Neurocognitive Profile of Attention-Deficit/Hyperactivity Disorder: A Review of Meta-Analyses". Archives of Clinical Neuropsychology. 33 (2): 143–157. doi:10.1093/arclin/acx055. PMID 29106438.
^Schoechlin C, Engel RR (August 2005). "Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data". Archives of Clinical Neuropsychology. 20 (6): 727–744. doi:10.1016/j.acn.2005.04.005. PMID 15953706.
^Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K (February 2013). "Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects". JAMA Psychiatry. 70 (2): 185–198. doi:10.1001/jamapsychiatry.2013.277. PMID 23247506.
^ abHoogman M, Muetzel R, Guimaraes JP, Shumskaya E, Mennes M, Zwiers MP, et al. (July 2019). "Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples". The American Journal of Psychiatry. 176 (7): 531–542. doi:10.1176/appi.ajp.2019.18091033. PMC 6879185. PMID 31014101.
^Brown TE (October 2008). "ADD/ADHD and Impaired Executive Function in Clinical Practice". Current Psychiatry Reports. 10 (5): 407–411. doi:10.1007/s11920-008-0065-7. PMID 18803914. S2CID 146463279.
^Cite error: The named reference Malenka pathways was invoked but never defined (see the help page).
^Diamond A (2013). "Executive functions". Annual Review of Psychology. 64: 135–168. doi:10.1146/annurev-psych-113011-143750. PMC 4084861. PMID 23020641. EFs and prefrontal cortex are the first to suffer, and suffer disproportionately, if something is not right in your life. They suffer first, and most, if you are stressed (Arnsten 1998, Liston et al. 2009, Oaten & Cheng 2005), sad (Hirt et al. 2008, von Hecker & Meiser 2005), lonely (Baumeister et al. 2002, Cacioppo & Patrick 2008, Campbell et al. 2006, Tun et al. 2012), sleep deprived (Barnes et al. 2012, Huang et al. 2007), or not physically fit (Best 2010, Chaddock et al. 2011, Hillman et al. 2008). Any of these can cause you to appear to have a disorder of EFs, such as ADHD, when you do not.
^ abcAntshel KM, Hier BO, Barkley RA (2014). "Executive Functioning Theory and ADHD". In Goldstein S, Naglieri JA (eds.). Handbook of Executive Functioning. New York, NY: Springer. pp. 107–120. doi:10.1007/978-1-4614-8106-5_7. ISBN 978-1-4614-8106-5.
^[9][10][11][12][13][14][15][16]
^Retz W, Stieglitz RD, Corbisiero S, Retz-Junginger P, Rösler M (October 2012). "Emotional dysregulation in adult ADHD: What is the empirical evidence?". Expert Review of Neurotherapeutics. 12 (10): 1241–1251. doi:10.1586/ern.12.109. PMID 23082740. S2CID 207221320.
^Faraone SV, Rostain AL, Blader J, Busch B, Childress AC, Connor DF, et al. (February 2019). "Practitioner Review: Emotional dysregulation in attention-deficit/hyperactivity disorder - implications for clinical recognition and intervention". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 60 (2): 133–150. doi:10.1111/jcpp.12899. PMID 29624671.
^Shaw P, Stringaris A, Nigg J, Leibenluft E (March 2014). "Emotion dysregulation in attention deficit hyperactivity disorder". The American Journal of Psychiatry. 171 (3): 276–293. doi:10.1176/appi.ajp.2013.13070966. PMC 4282137. PMID 24480998.
^[18][19][20]
^Fleming M, Fitton CA, Steiner MF, McLay JS, Clark D, King A, et al. (July 2017). "Educational and Health Outcomes of Children Treated for Attention-Deficit/Hyperactivity Disorder". JAMA Pediatrics. 171 (7): e170691. doi:10.1001/jamapediatrics.2017.0691. PMC 6583483. PMID 28459927.
^Lee YC, Yang HJ, Chen VC, Lee WT, Teng MJ, Lin CH, et al. (1 April 2016). "Meta-analysis of quality of life in children and adolescents with ADHD: By both parent proxy-report and child self-report using PedsQL™". Research in Developmental Disabilities. 51–52: 160–172. doi:10.1016/j.ridd.2015.11.009. PMID 26829402.
^Barkley RA, Fischer M (July 2019). "Hyperactive Child Syndrome and Estimated Life Expectancy at Young Adult Follow-Up: The Role of ADHD Persistence and Other Potential Predictors". Journal of Attention Disorders. 23 (9): 907–923. doi:10.1177/1087054718816164. PMID 30526189. S2CID 54472439.
^Cattoi B, Alpern I, Katz JS, Keepnews D, Solanto MV (April 2022). "The Adverse Health Outcomes, Economic Burden, and Public Health Implications of Unmanaged Attention Deficit Hyperactivity Disorder (ADHD): A Call to Action Resulting from CHADD Summit, Washington, DC, October 17, 2019". Journal of Attention Disorders. 26 (6): 807–808. doi:10.1177/10870547211036754. PMID 34585995. S2CID 238218526.
^"'A horrible, perfect storm': Frustrations rise as shortage of Adderall, other ADHD medication continues". Chicago Tribune. 12 February 2024. Retrieved 16 February 2024.
^ abBarkley RA, Murphy KR (1 June 2011). "The Nature of Executive Function (EF) Deficits in Daily Life Activities in Adults with ADHD and Their Relationship to Performance on EF Tests". Journal of Psychopathology and Behavioral Assessment. 33 (2): 137–158. doi:10.1007/s10862-011-9217-x. ISSN 1573-3505.
^Groen Y, Priegnitz U, Fuermaier AB, Tucha L, Tucha O, Aschenbrenner S, et al. (December 2020). "Testing the relation between ADHD and hyperfocus experiences". Research in Developmental Disabilities. 107: 103789. doi:10.1016/j.ridd.2020.103789. PMID 33126147.
^"APA PsycNet". psycnet.apa.org. Retrieved 3 March 2024.
^Ashinoff BK, Abu-Akel A (February 2021). "Hyperfocus: the forgotten frontier of attention". Psychological Research. 85 (1): 1–19. doi:10.1007/s00426-019-01245-8. PMC 7851038. PMID 31541305.
^Ishii S, Takagi S, Kobayashi N, Jitoku D, Sugihara G, Takahashi H (16 March 2023). "Hyperfocus symptom and internet addiction in individuals with attention-deficit/hyperactivity disorder trait". Frontiers in Psychiatry. 14: 1127777. doi:10.3389/fpsyt.2023.1127777. PMC 10061009. PMID 37009127.
^Worthington R, Wheeler S (January 2023). "Hyperfocus and offending behaviour: a systematic review" (PDF). The Journal of Forensic Practice. 25 (3): 185–200. doi:10.1108/JFP-01-2022-0005. ISSN 2050-8794. S2CID 258330884.
^Larsson H, Anckarsater H, Råstam M, Chang Z, Lichtenstein P (January 2012). "Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 53 (1): 73–80. doi:10.1111/j.1469-7610.2011.02467.x. PMID 21923806.
^Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, et al. (September 2013). "Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs". Nature Genetics. 45 (9): 984–994. doi:10.1038/ng.2711. PMC 3800159. PMID 23933821.
^Cecil CA, Nigg JT (November 2022). "Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential". Molecular Diagnosis & Therapy. 26 (6): 581–606. doi:10.1007/s40291-022-00609-y. PMC 7613776. PMID 35933504.
^Nigg JT, Sibley MH, Thapar A, Karalunas SL (December 2020). "Development of ADHD: Etiology, Heterogeneity, and Early Life Course". Annual Review of Developmental Psychology. 2 (1): 559–583. doi:10.1146/annurev-devpsych-060320-093413. PMC 8336725. PMID 34368774.
^"APA PsycNet". psycnet.apa.org. Retrieved 28 March 2024.
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^Franke B, Michelini G, Asherson P, Banaschewski T, Bilbow A, Buitelaar JK, et al. (October 2018). "Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan". European Neuropsychopharmacology. 28 (10): 1059–1088. doi:10.1016/j.euroneuro.2018.08.001. PMC 6379245. PMID 30195575.
^Sinopoli KJ, Schachar R, Dennis M (August 2011). "Traumatic brain injury and secondary attention-deficit/hyperactivity disorder in children and adolescents: The effect of reward on inhibitory control". Journal of Clinical and Experimental Neuropsychology. 33 (7): 805–819. doi:10.1080/13803395.2011.562864. ISSN 1380-3395. PMC 3184364. PMID 21598155.
^ ab"The Connection between Traumatic Brain Injury (TBI) and Attention-Deficit/Hyperactivity Disorder, Therapeutic Approaches". Retrieved 29 March 2024.
^Eme R (April 2012). "ADHD: an integration with pediatric traumatic brain injury". Expert Review of Neurotherapeutics. 12 (4): 475–483. doi:10.1586/ern.12.15. PMID 22449218. S2CID 35718630.
^Gerring JP, Brady KD, Chen A, Vasa R, Grados M, Bandeen-Roche KJ, et al. (1998). "Premorbid Prevalence of ADHD and Development of Secondary ADHD After Closed Head Injury". Journal of the American Academy of Child & Adolescent Psychiatry. 37 (6): 647–654. doi:10.1097/00004583-199806000-00015.
^Kennedy M, Kreppner J, Knights N, Kumsta R, Maughan B, Golm D, et al. (October 2016). "Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 57 (10): 1113–1125. doi:10.1111/jcpp.12576. PMC 5042050. PMID 27264475.
^Faraone SV, Banaschewski T, Coghill D, Zheng Y, Biederman J, Bellgrove MA, et al. (September 2021). "The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder". Neuroscience and Biobehavioral Reviews. 128: 789–818. doi:10.1016/j.neubiorev.2021.01.022. PMC 8328933. PMID 33549739.
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