Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels.[1] Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts of the body.[1] As clotting factors and platelets are used up, bleeding may occur.[1] This may include blood in the urine, blood in the stool, or bleeding into the skin.[1] Complications may include organ failure.[2]
Relatively common causes include sepsis, surgery, major trauma, cancer, and complications of pregnancy.[1] Less common causes include snake bites, frostbite, and burns.[1] There are two main types: acute (rapid onset) and chronic (slow onset).[1] Diagnosis is typically based on blood tests.[2] Findings may include low platelets, low fibrinogen, high INR, or high D-dimer.[2]
Treatment is mainly directed towards the underlying condition.[2][3] Other measures may include giving platelets, cryoprecipitate, or fresh frozen plasma.[2] Evidence to support these treatments, however, is poor.[2] Heparin may be useful in the slowly developing form.[2] About 1% of people admitted to hospital are affected by the condition.[4] In those with sepsis, rates are between 20% and 50%.[4] The risk of death among those affected varies from 20% to 50%.[4]
^ abcdefghij"Disseminated Intravascular Coagulation (DIC) - Hematology and Oncology". Merck Manuals Professional Edition. September 2016. Retrieved 20 December 2017.
^ abLevi M (2007). "Disseminated Intravascular Coagulation". Critical Care Medicine. 35 (9): 2191–2195. doi:10.1097/01.CCM.0000281468.94108.4B. PMID 17855836. S2CID 7158989.
^ abcdeGando S, Levi M, Toh CH (2 June 2016). "Disseminated intravascular coagulation". Nature Reviews Disease Primers. 2: 16037. doi:10.1038/nrdp.2016.37. PMID 27250996. S2CID 4059451.
and 27 Related for: Disseminated intravascular coagulation information
Disseminatedintravascularcoagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. Symptoms may include...
pointed ends. Several microangiopathic diseases, including disseminatedintravascularcoagulation and thrombotic microangiopathies, generate fibrin strands...
DNA) into the blood. Activation of the coagulation system may precipitate disseminatedintravascularcoagulation. High potassium levels may lead to potentially...
microvascular permeability are main characteristics of disseminatedintravascularcoagulation, a fatal complication of sepsis. Patients with this devastating...
process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation begins almost...
vision, nosebleeds, and seizures. Complications may include disseminatedintravascularcoagulation, placental abruption, and kidney failure. The cause is unknown...
the main complaint of the disseminated forms, leading the patient to seek treatment, whereas pulmonary symptoms in disseminated disease may be mild or even...
resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminatedintravascularcoagulation. Purpura fulminans...
blood film. In diseases such as hemolytic uremic syndrome, disseminatedintravascularcoagulation, thrombotic thrombocytopenic purpura, and malignant hypertension...
or absence of blood-clotting proteins, known as clotting factors or coagulation factors. Genetic disorders, such as hemophilia and Von Willebrand disease...
advanced illness resulting in a medical emergency known as disseminatedintravascularcoagulation (DIC). There are various methods for determining the clotting...
heart rate abnormalities, severe maternal hemorrhage, and disseminatedintravascularcoagulation (DIC). Those abruptions caused by venous bleeding at the...
thrombocytopenic, or international normalized ratio (INR) > 2 Disseminatedintravascularcoagulation Kidney dysfunction serum creatinine ≥ 2 times the upper...
developmental anomalies. In those with deficits in immune function, disseminated shingles may occur (wide rash). It is defined as more than 20 skin lesions...
degradation product (FDP) testing is commonly used to diagnose disseminatedintravascularcoagulation. A tumor marker known as AMDL-ELISA DR-70 (FDP), and now...
type II), tumours that block or hoard blood supply, and disseminatedintravascularcoagulation or other thromboses. Gas gangrene can cause myonecrosis...
by fulminant meningococcemia, adrenal insufficiency, and disseminatedintravascularcoagulation. Not all instances of a purpura-like rash are due to meningococcal...
the coagulation cascade creating an over production of blood clots with the inability to be broken down resulting in DIC or DisseminatedIntravascular Coagulation...
mechanism is thought to be due to disseminatedintravascularcoagulation, along with dilution of recipient platelets and coagulation factors. Close monitoring...
Global Information