Delivery of the baby as soon as possible, management of blood pressure[1][2]
Prognosis
<1% risk of death (mother); 7.3% to 11.9% risk of death (child)[3]
Frequency
~0.7% of pregnancies[2]
HELLP syndrome is a complication of pregnancy; the acronym stands for hemolysis, elevated liver enzymes, and low platelet count.[1] It usually begins during the last three months of pregnancy or shortly after childbirth.[1] Symptoms may include feeling tired, retaining fluid, headache, nausea, upper right abdominal pain, blurry vision, nosebleeds, and seizures.[1] Complications may include disseminated intravascular coagulation, placental abruption, and kidney failure.[1]
The cause is unknown.[1] The condition occurs in association with pre-eclampsia or eclampsia.[1] Other risk factors include previously having the syndrome and a mother older than 25 years.[1] The underlying mechanism may involve abnormal placental development.[4] Diagnosis is generally based on blood tests finding signs of red blood cell breakdown (lactate dehydrogenase greater than 600 U/L), an aspartate transaminase greater than 70 U/L, and platelets less than 100×109/l.[2] If not all the criteria are present, the condition is incomplete.[2]
Treatment generally involves delivery of the baby as soon as possible.[1] This is particularly true if the pregnancy is beyond 34 weeks of gestation.[2] Medications may be used to decrease blood pressure and blood transfusions may be required.[1]
HELLP syndrome occurs in about 0.7% of pregnancies and affects about 15% of women with eclampsia or severe pre-eclampsia.[5][2] Death of the mother is uncommon (< 1%).[1][3] Outcomes in the babies are generally related to how premature they are at birth.[1] The syndrome was first named in 1982 by American gynaecologist Louis Weinstein.[2]
^ abcdefghijklmnop"HELLP syndrome". Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. 2018. Retrieved 5 October 2018.
^ abcdefghijHaram K, Svendsen E, and Abildgaard U (February 2009). "The HELLP syndrome: clinical issues and management. A Review". BMC Pregnancy Childbirth. 9: 8. doi:10.1186/1471-2393-9-8. PMC 2654858. PMID 19245695.
^ abOdze, Robert D.; Goldblum, John R. (2009). Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. Elsevier Health Sciences. p. 1240. ISBN 9781416040590.
^Cohen, Hannah; O'Brien, Patrick (2015). Disorders of Thrombosis and Hemostasis in Pregnancy: A Guide to Management. Springer. p. 305. ISBN 9783319151205.
^"Preeclampsia and Eclampsia". Merck Manuals Consumer Version. March 2018. Retrieved 5 October 2018.
HELLPsyndrome is a complication of pregnancy; the acronym stands for hemolysis, elevated liver enzymes, and low platelet count. It usually begins during...
important point for most health care purposes. This classification treats HELLPsyndrome as a type of preeclampsia rather than a parallel entity. Chronic hypertension...
such as hyperemesis gravidarum was 103.5 IU/L, pre-eclampsia was 115, HELLPsyndrome was 149. ALT levels would reduce by greater than 50% in three days after...
(disambiguation) Help me (disambiguation) HELP University, Malaysia HELLPSyndrome, a medical condition affecting pregnant women All pages with titles...
coagulation, thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, HELLPsyndrome, malfunctioning cardiac valves etc. In most of the conditions,...
called "parasitic hemolysis" in medical literature.[citation needed] See HELLPsyndrome, Pre-eclampsia, and Eclampsia Hemolytic disease of the newborn is an...
unaffected and may be used to distinguish mirror syndrome from HELLPsyndrome. In most cases, Ballantyne syndrome causes fetal or neonatal death. In contrast...
pressure greater than 160/110, with additional medical signs and symptoms. HELLPsyndrome is a type of pre-eclampsia. It is a combination of three medical conditions:...
symptoms, and later rights itself, but it can develop into pre-eclampsia. HELLPsyndrome – Hemolytic anemia, elevated liver enzymes and a low platelet count...
as scleroderma), the pregnancy-associated HELLP (hemolysis, liver dysfunction, and low platelets) syndrome, and toxic drug reaction (e.g., to cocaine...
seizures occur, which can be fatal. Preeclamptic patients with the HELLPsyndrome show liver failure and disseminated intravascular coagulation (DIC)...
associated with some serious diseases of pregnancy, including pre-eclampsia, HELLPsyndrome and acute fatty liver of pregnancy. These cause DI by impairing hepatic...
she may experience pregnancy-induced high blood pressure and develop HELLPsyndrome. The baby has a high risk of being born prematurely and will have a...
considered by the treating clinician. These include preeclampsia, the HELLPsyndrome, and acute fatty liver of pregnancy. Furthermore, other causes of hepatitis...
consideration. These include obstetrical causes such as pre-eclampsia, HELLPsyndrome (hemolysis, elevated liver enzymes and low platelets), or thrombotic...
disorders can be acquired as well, such as in HELLPsyndrome, which is due to pregnancy, or Hemolytic-uremic syndrome (HUS), which is due to E. coli toxins....
Trista was diagnosed with gestational diabetes that escalated into HELLPsyndrome. In July 2007, Maxwell Alston was born four weeks early stemming from...
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