Time taken for a blood sample to coagulate outside the body
Clotting time
Specialty
Haematology
MeSH
D014914
MedlinePlus
003652
[edit on Wikidata]
Clotting time is a general term for the time required for a sample of blood to form a clot, or, in medical terms, coagulate. The term "clotting time" is often used when referring to tests such as the prothrombin time (PT), activated partial thromboplastin time (aPTT or PTT), activated clotting time (ACT), thrombin time (TT), or Reptilase time. These tests are coagulation studies performed to assess the natural clotting ability of a sample of blood. In a clinical setting, healthcare providers will order one of these tests to evaluate a patient's blood for any abnormalities in the time it takes for their blood to clot.[1] Each test involves adding a specific substance to the blood and measuring the time until the blood forms fibrin which is one of the first signs of clotted blood.[2] Each test points to a different component of the clotting sequence which is made up of coagulation factors that help form clots. Abnormal results could be due to a number of reasons including, but, not limited to, deficiency in clotting factors, dysfunction of clotting factors, blood-thinning medications, medication side-effects, platelet deficiency, inherited bleeding or clotting disorders, liver disease, or advanced illness resulting in a medical emergency known as disseminated intravascular coagulation (DIC).[3]
^Epstein KL (January 2015). "Chapter 119 - Evaluation of Hemostasis". In Sprayberry KA, Robinson NE (eds.). Robinson's Current Therapy in Equine Medicine (Seventh ed.). St. Louis: W.B. Saunders. pp. 500–502. doi:10.1016/b978-1-4557-4555-5.00119-9. ISBN 978-1-4557-4555-5.
^Weisel JW, Litvinov RI (March 2013). "Mechanisms of fibrin polymerization and clinical implications". Blood. 121 (10): 1712–1719. doi:10.1182/blood-2012-09-306639. PMC 3591795. PMID 23305734.
^Yang R, Moosavi L (2023). "Prothrombin Time". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 31334989. Retrieved 2023-11-08.
Clottingtime is a general term for the time required for a sample of blood to form a clot, or, in medical terms, coagulate. The term "clottingtime" is...
that do not pre-warm the vial or sample may see increased time to clotting because clotting times increase with temperature. A common reference range...
clottingtime (KCCT), reflecting kaolin and cephalin as materials historically used in the test. Apart from detecting abnormalities in blood clotting...
Kaolin clottingtime (KCT) is a sensitive test to detect lupus anticoagulants. There is evidence that suggests it is the most sensitive test for detecting...
The thrombin time (TT), also known as the thrombin clottingtime (TCT), is a blood test that measures the time it takes for a clot to form in the plasma...
Ecarin clottingtime (ECT) is a laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally...
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the...
erroneously referred to as "clotting disorders", but a clotting disorder is the opposite, defined as a predisposition to excessive clot formation (thrombus)...
do not interact with clotting are available for patients on anticoagulants. However, some foods and supplements encourage clotting. These include alfalfa...
dependent clotting factors II, VII, IX, and X. Bleeding time with heparin and warfarin therapy can be measured with the partial thromboplastin time (PTT)...
cool slowly. During this time, the cream content rises to the surface and forms "clots" or "clouts", hence the name. Clotted cream is an essential ingredient...
which occurs due to low amounts of clotting factor VIII, and haemophilia B, which occurs due to low levels of clotting factor IX. They are typically inherited...
patient plasma is mixed with normal pooled plasma and the clotting is reassessed. If a clotting inhibitor such as a lupus anticoagulant is present, the...
thus slow down clot formation by preventing the conversion of fibrinogen to fibrin. This effect can be seen in the thrombin clottingtime (TCT) test, which...
added clotting factor. The clotting test performed immediately after the specimens are mixed may show correction because the antibody has not had time to...
blood of some of the haemophilic patients with a greatly prolonged clottingtime ... when added to other haemophilic blood possessed a coagulant action...
carinatus venom is called ecarin and is the primary reagent in the ecarin clottingtime (ECT) test, which is used to monitor anticoagulation during treatment...
PTT (plus 80:20 mix), dilute Russell's viper venom time, silica clottingtime and prothrombin time (using a lupus-sensitive thromboplastin) are the principal...
is also called protime INR and PT/INR. They are used to determine the clotting tendency of blood, in such things as the measure of warfarin dosage, liver...
service Energy Charter Treaty, for cross-border cooperation Ecarin clottingtime Ectomesenchymal chondromyxoid tumor Electrochemotherapy Electroconvulsive...
cognitive-behavioral therapy Acetylcholine, (ACt/ACh) a neurotransmitter Activated clottingtime, a test of coagulation Adoptive cell transfer, transfer of cells into...
Railway, terminal railroad in the Kansas City metropolitan area Kaolin clottingtime, a medical test used to detect lupus anticoagulant Kungchantang, the...
blood clots includes the use of medications that interrupt the complex clotting cascade and changing the proteins that are needed for clotting. Antiplatelet...
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