Cave disease,[1]Darling's disease,[1]Ohio valley disease,[1]Reticuloendotheliosis,[1]Spelunker's lung and Caver's disease
Histoplasma capsulatum. Methenamine silver stain showing histopathologic changes in histoplasmosis
Specialty
Infectious disease
Histoplasmosis is a fungal infection caused by Histoplasma capsulatum.[2][3] Symptoms of this infection vary greatly, but the disease affects primarily the lungs.[4] Occasionally, other organs are affected; called disseminated histoplasmosis, it can be fatal if left untreated.
H. capsulatum is found in soil, often associated with decaying bat guano or bird droppings. Disruption of soil from excavation or construction releases infectious spores that can be inhaled by humans. H. capsulatum has a one to two week incubation period within human lungs before symptoms arise.[5] The disease is common among AIDS patients due to their immunosuppression.[6]
From 1938 to 2013 in the US, 105 outbreaks were reported in a total of 26 states plus Puerto Rico. In 1978 to 1979 during a large urban outbreak in which 100,000 people were exposed to the fungus in Indianapolis,[7] victims had pericarditis, rheumatological syndromes, esophageal and vocal cord ulcers, parotitis, adrenal insufficiency, uveitis, fibrosing mediastinitis, interstitial nephritis, intestinal lymphangiectasia, and epididymitis. Histoplasmosis mimics colds, pneumonia, and the flu, and can be shed by bats in their feces.
^ abcdRapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
^Johnstone RB (2017). "25. Mycoses and Algal infections". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 452. ISBN 978-0-7020-6830-0.
^Stenn F (February 1960). "Cave disease or speleonosis". Archives of Internal Medicine. 105 (2): 181–3. doi:10.1001/archinte.1960.00270140003001. PMID 13834312.
^Ryan KJ, Ray CG, eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 674–6. ISBN 978-0-8385-8529-0.
^Pendergast M (2010). Inside the Outbreaks: The Elite Medical Detectives of the Epidemic Intelligence Service. Houghton Mifflin Harcourt. pp. 13–14. ISBN 9780151011209.
^Cotran RS, Kumar V, Fausto N, Robbins SL, Abbas AK (2005). Robbins and Cotran Pathologic Basis of Disease. St. Louis: Elsevier/Saunders. pp. 754–5. ISBN 978-0-7216-0187-8.
^Center ER (April 12, 2021). "Histoplasmosis: A Hoosier Concern". Epidemiology Resource Center.
epididymitis. Histoplasmosis mimics colds, pneumonia, and the flu, and can be shed by bats in their feces. If symptoms of histoplasmosis infection occur...
Granulomas are seen in most forms of histoplasmosis (acute histoplasmosis, histoplasmoma, chronic histoplasmosis). Histoplasma organisms can sometimes...
"[African histoplasmosis due to Histoplasma capsulatum var. duboisii: relationship with AIDS in recent Congolese cases]" [African histoplasmosis due to Histoplasma...
PMID 24860719. "Histoplasmosis statistics". Centers for Disease Control and Prevention. 13 August 2018. Retrieved 10 August 2019. "U.S. Histoplasmosis Maps". Centers...
Systemic fungal infections are more serious and include cryptococcosis, histoplasmosis, pneumocystis pneumonia, aspergillosis and mucormycosis. Signs and symptoms...
There are a number of other rare pulmonary manifestations of histoplasmosis. Histoplasmosis, like blastomycosis, may disseminate haematogenously to infect...
Presumed ocular histoplasmosis syndrome (POHS) is a syndrome affecting the eye, which is characterized by peripheral atrophic chorioretinal scars, atrophy...
histoplasmosis is a rare skin condition, reported on the penis, characterized by a chancre-type lesion with regional adenopathy.: 316 Histoplasmosis...
disseminated histoplasmosis is an infection caused by Histoplasma capsulatum, and most people who develop this severe form of histoplasmosis are immunocompromised...
Greek word καρκίνος (karkínos), also meaning "crab". Primary cutaneous histoplasmosis chancres thefreedictionary[full citation needed] Hook, Edward W. (2012)...
infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously...
Primary pulmonary histoplasmosis is caused by inhalation of Histoplasma capsulatum spores, and approximately 10% of people with this acute infection develop...
degree of cross-reactivity with other endemic fungal conditions such as histoplasmosis, and thus cannot distinguish blastomycosis from other similar conditions...
the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage...
Treatment is anti-retroviral therapy. Disseminated histoplasmosis: During a large urban disseminated histoplasmosis outbreak (est. 100,000 victims) in Indianapolis...
with a life-threatening heart infection, pericarditis, brought on by histoplasmosis. His scheduled European tour was canceled, but Dylan made a speedy recovery...
include aspergillosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mycetomas, and paracoccidioidomycosis. Furthermore, a person with immunodeficiency...
includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. It is also used to prevent candidiasis...
states under pathogenic conditions. They are the causative agents of histoplasmosis in humans and epizootic lymphangitis in horses. Histoplasma species...
jiroveci (pneumocystis pneumonia, or PCP), and Coccidioides immitis. Histoplasmosis is most common in the Mississippi River basin, and coccidioidomycosis...
is an alternative For treatment of chronic pulmonary aspergillosis, histoplasmosis, sporotrichosis, paracoccidioidomycosis, mycoses caused by Talaromyces...
Global Information