Inhibit fibrin formation in the final common pathway of the coagulation cascade
Chemical class
Direct factor Xa inhibitors[1]
Legal status
In Wikidata
Direct factor Xa inhibitors (xabans) are anticoagulants (blood thinning drugs), used to both treat and prevent blood clots in veins, and prevent stroke and embolism in people with atrial fibrillation (AF).[2][3]
^"WHOCC – ATC/DDD Index". whocc.no. Archived from the original on 4 April 2021. Retrieved 4 April 2021.
^Cite error: The named reference Hitchings2019 was invoked but never defined (see the help page).
^Cite error: The named reference Turgeon2018 was invoked but never defined (see the help page).
and 28 Related for: Direct factor Xa inhibitors information
DirectfactorXainhibitors (xabans) are anticoagulants (blood thinning drugs), used to both treat and prevent blood clots in veins, and prevent stroke...
modified human factorXa decoy that reverses the effect of factorXainhibitors by binding at the active sites of factorXainhibitor and making it catalytically...
warfarin it has fewer interactions with other medications. It is a directfactorXainhibitor. In 2007, Pfizer and Bristol-Myers Squibb began development of...
drugs show large differences in half-life between individuals. DirectfactorXainhibitors (xabans) such as rivaroxaban and apixaban are a newer class of...
drugs from the class of directXainhibitors are marketed worldwide. Rivaroxaban (Xarelto) was the first approved FXa inhibitor to become commercially...
name AndexXa. Rivaroxaban inhibits both free and bound FactorXa in the prothrombinase complex. It is a selective directfactorXainhibitor with an onset...
free form. These directfactorXainhibitors can be administered orally, as can dabigatran etexilate, which is a direct thrombin inhibitor. Fondaparinux...
name Lixiana among others, is an anticoagulant medication and a directfactorXainhibitor. It is taken by mouth. Compared with warfarin it has fewer drug...
(trade name Bevyxxa) is an oral anticoagulant drug which acts as a directfactorXainhibitor. Betrixaban is FDA approved for venous thrombosis prevention in...
Unlike directfactorXainhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factorXa. Fondaparinux...
shifted towards factorXainhibitors, or even dual thrombin and fXainhibitors that have a broader mechanism of action by both inhibitingfactor IIa (thrombin)...
uncontrolled bleeding. It has not been found to be useful for other factorXainhibitors. It is given by injection into a vein. Common side effects include...
the action of antithrombin on thrombin and factorXa. A newer class of drugs, the direct thrombin inhibitors, is under development; some members are already...
Darexaban (YM150) is a directinhibitor of factorXa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic...
there is low certainty evidence to suggest that treatment with directfactorXainhibitors may help prevent symptomatic VTEs, however this treatment approach...
antithrombin to thrombin (as well as factorXa). The direct thrombin inhibitors, a newer class of medication, directly inhibit thrombin by binding to its active...
Otamixaban (INN) is an experimental injectable anticoagulant directfactorXainhibitor that was investigated for the treatment for acute coronary syndrome...
protein antistasin, which prevents blood clotting by inhibitingfactorXa. DirectfactorXainhibitor "Haementeria officinalis de Filippi, 1849". Interim...
(andexanet alfa), the First and Only Antidote for the Reversal of FactorXaInhibitors, PM Portola, April 26, 2019". portola.com. Retrieved May 11, 2019...
in which the A2 domain of Factor V is dissociated from the rest of the protein. Protein S also binds to FactorXa, inhibiting the latter from diminishing...
prothrombinase (FactorXa along with Factor Va as a cofactor), in the final states of coagulation. Fibrin is then cross linked by factor XIII (Fibrin Stabilizing...
levels (usually below 70). The direct oral anticoagulants (DOACs) such as the factorXainhibitors or direct thrombin inhibitors are thought to have a lower...
Fibrillation: Analysis From the ROCKET AF Trial (Rivaroxaban Once-Daily, Oral, DirectFactorXa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke...
inflammatory response of airway smooth muscle of those patients. CD38 inhibitors may be used as therapeutics for the treatment of asthma. CD38 has been...
disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors. Acquired haemophilia can be associated with cancers...
Global Information