Protein S deficiency is a disorder associated with increased risk of venous thrombosis.[1] Protein S, a vitamin K-dependent physiological anticoagulant, acts as a nonenzymatic cofactor to activate protein C in the degradation of factor Va and factor VIIIa.[3]
Decreased (antigen) levels or impaired function of protein S leads to decreased degradation of factor Va and factor VIIIa and an increased propensity to venous thrombosis. Some risk factors for deep vein thrombosis or pulmonary embolism in patients with protein S deficiency include pregnancy, older age, hormonal therapy, consumption of birth control pills, recent surgery, trauma, and physical inactivity.[4] Protein S circulates in human plasma in two forms: approximately 60 percent is bound to complement component C4b β-chain while the remaining 40 percent is free, only free protein S has activated protein C cofactor activity[medical citation needed]
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PROS1 gene can lead to ProteinSdeficiency which is a rare blood disorder which can lead to an increased risk of thrombosis. ProteinS has been shown to interact...
subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins...
Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The disease belongs to a group of...
people with proteinSdeficiency, IgA deficiency, or heart failure. Fresh frozen plasma is made up of a complex mixture of water, proteins, carbohydrates...
thrombosis. The main ones are antithrombin III deficiency, protein C deficiency and proteinSdeficiency. Milder rare congenital thrombophilias are factor...
tightly bound to the protein transferrin. There are several mechanisms that control iron metabolism and safeguard against iron deficiency. The main regulatory...
qualitative deficiency of either (protein C or proteinS) may lead to thrombophilia (a tendency to develop thrombosis). Impaired action of Protein C (activated...
Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a...
TPN preparations. Proteindeficiency (not certain): A shortage of proteins involved in biotin homeostasis can cause biotin deficiency. The main problems...
power per unit time into frequency components composing that signal. ProteinSdeficiency Post-stroke depression Postsynaptic density, a specialization of...
iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and...
associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier. Glucose Transporter Type 1 Deficiency Syndrome has...
rarely, by nutritional vitamin K1 deficiency. As a result, Gla-residues are inadequately formed and the Gla-proteins are insufficiently active.[citation...
recognized as an entity in OMIM. It can present in conjunction with proteinSdeficiency and factor V Leiden. It is not currently known if sticky platelet...
been identified. Acquired protein C deficiency is caused by either depletion of available protein C in plasma or decreased protein C synthesis (caused by...
Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins. Because of redundancies in the...
C Von Willebrand disease Disseminated intravascular coagulation ProteinSdeficiency Antiphospholipid syndrome Disorders of platelets Thrombocytopenia...
additional thrombophilic condition (e.g., antithrombin deficiency, protein C deficiency, or proteinSdeficiency), should be considered for lifelong oral anticoagulation...
embolism. Those with familial clotting disorders such as proteinSdeficiency, protein C deficiency, or factor V Leiden are also at increased risk of thrombophlebitis...
Other causes of reactive thrombocythemia include: post surgery, iron deficiency, drugs, and rebound effect after bone marrow suppression. Research suggests...
V Leiden, prothrombin mutation G20210A, protein C deficiency, proteinSdeficiency, antithrombin deficiency, hyperhomocysteinemia and plasminogen/fibrinolysis...
syndrome, microsomal triglyceride transfer proteindeficiency disease, MTP deficiency, and betalipoprotein deficiency syndrome) is a disorder characterized...
vitamin E deficiency or 'ataxia with isolated with vitamin E deficiency', caused by mutations in the gene for the tocopherol transfer protein. These individuals...
soon after, ProteinS was recognised as a cofactor by Walker. In 1982, a family study by Griffin et al. first associated protein C deficiency with symptoms...
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