Vitamin K antagonists (VKA) are a group of substances that reduce blood clotting by reducing the action of vitamin K. The term "vitamin K antagonist" is technically a misnomer, as the drugs do not directly antagonize the action of vitamin K in the pharmacological sense, but rather the recycling of vitamin K. Vitamin K antagonists (VKAs) have been the mainstay of anticoagulation therapy for more than 50 years.
They are used as anticoagulant medications in the prevention of thrombosis, and in pest control, as rodenticides.
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VitaminK is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin...
and a life-threatening bleeding rate of 1-3% per year. Newer non-vitaminKantagonist oral anticoagulants appear to have fewer life-threatening bleeding...
Acenocoumarol is an anticoagulant that functions as a vitaminKantagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed...
Brodifacoum is a highly lethal 4-hydroxycoumarin vitaminKantagonist anticoagulant poison. In recent years, it has become one of the world's most widely...
the vitaminKantagonist at an adjusted lower dose when the target INR is reached. For people who need rapid reversal of the vitaminKantagonist – such...
Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitaminKantagonist type used as a rodenticide. Coumatetralyl is commonly used with grains...
rodenticide. It is a second-generation 4-hydroxycoumarin derivative and vitaminKantagonist, often called a "super-warfarin" for its added potency and tendency...
drug to be taken by mouth, and a coumarin derivative. It acts as a vitaminKantagonist and inhibits blood clotting (coagulation) by blocking synthesis of...
Difenacoum is an anticoagulant of the 4-hydroxycoumarin vitaminKantagonist type. It has anticoagulant effects and is used commercially as a rodenticide...
VitaminK deficiency results from insufficient dietary vitamin K1 or vitamin K2 or both. Symptoms include bruising, petechiae, and haematoma. Vitamin...
VitaminK reactions are adverse side effects that may occur after injection with vitaminK. The liver utilizes vitaminK to produce coagulation factors...
Vitamin K2 or menaquinone (MK) (/ˌmɛnəˈkwɪnoʊn/) is one of three types of vitaminK, the other two being vitamin K1 (phylloquinone) and K3 (menadione)...
a vitaminKantagonist, warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1...
Phenindione is an anticoagulant which functions as a VitaminKantagonist. Phenindione was introduced in the early 1950s. It acts similar to warfarin,...
be taken by mouth, and these oral medicines include warfarin (a vitaminKantagonist), rivaroxaban (a factor Xa inhibitor), apixaban (a factor Xa inhibitor)...
Fluindione is a vitaminKantagonist It is used as an anticoagulant. Mentré F, Pousset F, Comets E, et al. (January 1998). "Population pharmacokinetic-pharmacodynamic...
de Veer AJ, Bode K, Mahmoodi BK, Dewilde WJ, Lip GY, et al. (March 2018). "Efficacy and Safety of the Use of Non-VitaminKAntagonist Oral Anticoagulants...
Superwarfarins are highly potent vitaminKantagonist anticoagulants that are used as rodenticides. They are called superwarfarins because they are much...
fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitaminKantagonist type. It is a second generation (i.e., high potency) chemical in...
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which...
Diphenadione is a vitaminKantagonist that has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other...
2019). "VitaminK and Bone Health: A Review on the Effects of VitaminK Deficiency and Supplementation and the Effect of Non-VitaminKAntagonist Oral Anticoagulants...
anticoagulants to increase the risk of bleeding. Dosage adjustment of vitaminKantagonist may be necessary. Statins: Combination of statins and fenofibrate...
(first generation) rodenticides, acting by effective blocking of the vitamin-K cycle, resulting in inability to produce essential blood-clotting factors—mainly...