Structure of hirudin (ball-stick model) in complex with thrombin (ribbon model).[1]
Identifiers
Symbol
Hirudin
Pfam
PF00713
InterPro
IPR000429
SCOP2
4htc / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as Hirudo medicinalis) that has a blood anticoagulant property.[2] This is essential for the leeches' habit of feeding on blood, since it keeps a host's blood flowing after the worm's initial puncture of the skin.
Hirudin (MEROPS I14.001) belongs to a superfamily (MEROPS IM) of protease inhibitors that also includes haemadin (MEROPS I14.002) and antistasin (MEROPS I15).[3][4]
^PDB: 4HTC
^"IV. On the action of a secretion obtained from the medicinal leech on the coagulation of the blood". Proceedings of the Royal Society of London. 36 (228–231): 478–487. 1883. doi:10.1098/rspl.1883.0135.
Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as Hirudo medicinalis) that has a blood anticoagulant property...
with a sucker and feeding on blood, having first secreted the peptide hirudin to prevent the blood from clotting. The jaws used to pierce the skin are...
piercing the skin, they suck out blood while injecting anticoagulants (hirudin). Large adults can consume up to ten times their body weight in a single...
recently, is the allosteric inhibitors. Hirudin and derivatives were originally discovered in Hirudo medicinalis: Hirudin Bivalirudin (transient inhibition...
injection. Lepirudin is a recombinant hirudin derived from yeast cells. Lepirudin is almost identical to hirudin extracted from Hirudo medicinalis, having...
substances in the saliva of several hematophagous species, such as leeches (hirudin). Hematophagy is classified as either obligatory or facultative. Obligatory...
technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before...
the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged...
inside of a circle. After piercing the skin and injecting anticoagulants (hirudin) and anaesthetics, they suck out blood, consuming up to ten times their...
laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva...
(ECT) test, which is used to monitor anticoagulation during treatment with hirudin. Yet another drug produced from E. carinatus venom is Aggrastat (Tirofiban)...
thrombin inhibitor. Current members of this class include the bivalent drugs hirudin, lepirudin, and bivalirudin and the monovalent drugs argatroban and dabigatran...
based on compounds found in animals. For example, the anticoagulant drugs, hirudin and its synthetic congener, bivalirudin, are based on saliva chemistry...
Haycraft, discovered an anticoagulant created by the leech, which he named hirudin John Rippiner Heath, physician and composer Micaiah John Muller Hill, FRS...
paved way for the first successful synthetic anticoagulants including hirudin. The monitoring of warfarin and keeping the international normalized ratio...
Chemically, it is a synthetic congener of the naturally occurring drug hirudin, found in the saliva of the medicinal leech Hirudo medicinalis. It is manufactured...
to a superfamily (MEROPS IM) of protease inhibitors that also includes hirudin (MEROPS I14.001) and antistasin (MEROPS I15). Richardson JL, Kroger B,...
COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS 1tmu: CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES...
Genre Label Ref. May 1 American Aquarium Lamentations New West Austra Hirudin Electronic Domino Boston Manor Glue Alternative rock Pure Noise Caleb Landry...
activation mechanism of this enzyme, and of the complex of thrombin with hirudin, which showed the molecular mechanism of inhibition of blood clotting by...
"Yes Exactly" 2020 Kane West & Thomas Van Party — "Mountain Baby" Austra HiRUDiN "Anywayz" Co-writer "Show Me What" A. G. Cook 7G Featured artist "Wish...
and C4b-binding protein levels in plasma anticoagulated with citrate or hirudin". Blood. 79 (12): 3203–11. doi:10.1182/blood.V79.12.3203.bloodjournal79123203...
1-methyl ester) is a dipeptide. At the high end there is the anticoagulant hirudin, MW ≈ 7000, which is composed of 65 amino acids. Apart from pharmaceuticals...
against time on the computer screen. The manufacturer recommends the use of hirudin as anticoagulant for samples to be tested, but studies have shown that...
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