Complex that catalyzes conversion of prothrombin to thrombin
The prothrombinase enzyme complex consists of factor Xa (a serine protease) and factor Va (a protein cofactor). The complex assembles on negatively charged phospholipid membranes in the presence of calcium ions. The prothrombinase complex catalyzes the conversion of prothrombin (factor II), an inactive zymogen, to thrombin (factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation cascade, which functions to regulate hemostasis in the body. To produce thrombin, the prothrombinase complex cleaves two peptide bonds in prothrombin, one after Arg271 and the other after Arg320.[1] Although it has been shown that factor Xa can activate prothrombin when unassociated with the prothrombinase complex, the rate of thrombin formation is severely decreased under such circumstances. The prothrombinase complex can catalyze the activation of prothrombin at a rate 3 x 105-fold faster than can factor Xa alone.[2] Thus, the prothrombinase complex is required for the efficient production of activated thrombin and also for adequate hemostasis.
^Krishnaswamy S (January 2005). "Exosite-driven substrate specificity and function in coagulation". J. Thromb. Haemost. 3 (1): 54–67. doi:10.1111/j.1538-7836.2004.01021.x. PMID 15634266. S2CID 478828.
^Nesheim ME, Taswell JB, Mann KG (November 1979). "The contribution of bovine Factor V and Factor Va to the activity of prothrombinase". J. Biol. Chem. 254 (21): 10952–62. doi:10.1016/S0021-9258(19)86616-4. PMID 500617.
The prothrombinase enzyme complex consists of factor Xa (a serine protease) and factor Va (a protein cofactor). The complex assembles on negatively charged...
optimized when factor Xa is complexed with activated co-factor V in the prothrombinase complex. Factor Xa is inactivated by protein Z-dependent protease inhibitor...
gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin. Thrombin (Factor IIa) (EC 3.4.21.5...
factor pathway inhibitor (TFPI). FXa and its co-factor FVa form the prothrombinase complex, which activates prothrombin to thrombin. Thrombin then activates...
coagulation, uninhibited factor Xa forms a prothrombinase complex with factor Va on platelet surfaces. Prothrombinases turn prothrombins to thrombins. Thrombins...
Thrombin is produced from prothrombin, by the action of an enzyme, prothrombinase (Factor Xa along with Factor Va as a cofactor), in the final states...
The thereby activated factor V (now called FVa) is a cofactor of the prothrombinase complex: The activated factor X (FXa) enzyme requires calcium and activated...
and cardiac arrest. One of the main components of the venom is the prothrombinase complex pseutarin-C, which breaks down prothrombin. John White, the...
Quinn-Allen, M. A.; Kane, W. H.; Lentz, B. R. (2011). "Modulation of Prothrombinase Assembly and Activity by Phosphatidylethanolamine". Journal of Biological...
X activators, and anticoagulant activities (including inhibitors of prothrombinase complex formation, inhibitors of thrombin, phospholipases, and protein...
AndexXa. Rivaroxaban inhibits both free and bound Factor Xa in the prothrombinase complex. It is a selective direct factor Xa inhibitor with an onset...
platelet membrane surface. These phospholipids then bind the tenase and prothrombinase complexes, two of the sites of interplay between platelets and the coagulation...
a crucial element in blood clotting; together they are part of the prothrombinase complex.: 26S Cofactors in the inactivation of Factor Va and Factor...
intrinsic blood coagulation pathway. β2-GP1 causes a reduction of the prothrombinase binding sites on platelets and reduces the activation caused by collagen...
prothrombin to thrombin, such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase). In Scott syndrome, the mechanism for translocating PS to the platelet...
1993). "Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C". J. Biol. Chem. 268 (4)...
both CD4+ and CD8+ T cells. Membrane bound FGL2 (mFGL2) exhibits a prothrombinase activity, resulting in fibrin deposition, vascular thrombosis and tissue...
Several enzyme complexes of blood coagulation cascade such as tenase and prothrombinase are activated by the cell surface exposure of the phosphatidylserine...
two distinct exosites is required for activation of prothrombin by prothrombinase". Journal of Thrombosis and Haemostasis. 1 (Supplement 1). Archived...
Zwaal RF, Hemker HC: The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980, 255:274-83. Bevers EM, Comfurius P, van Rijn...
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