positive regulation of cytosolic calcium ion concentration
response to progesterone
female pregnancy
negative regulation of apoptotic process
response to hydroperoxide
positive regulation of transcription, DNA-templated
positive regulation of cell growth
positive regulation of B cell proliferation
positive regulation of vasoconstriction
long-term depression
apoptotic signaling pathway
response to hormone
negative regulation of transcription, DNA-templated
signal transduction
positive regulation of insulin secretion
negative regulation of bone resorption
NAD metabolic process
positive regulation of cell population proliferation
negative regulation of neuron projection development
artery smooth muscle contraction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
952
12494
Ensembl
ENSG00000004468
ENSMUSG00000029084
UniProt
P28907
P56528
RefSeq (mRNA)
NM_001775
NM_007646
RefSeq (protein)
NP_001766
NP_031672
Location (UCSC)
Chr 4: 15.78 – 15.85 Mb
Chr 5: 44.03 – 44.07 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein[5] found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.[6]
In humans, the CD38 protein is encoded by the CD38 gene which is located on chromosome 4.[7][8]CD38 is a paralog of CD157, which is also located on chromosome 4 (4p15) in humans.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000004468 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029084 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Orciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R (October 2008). "CD38 is constitutively expressed in the nucleus of human hematopoietic cells". Journal of Cellular Biochemistry. 105 (3): 905–12. doi:10.1002/jcb.21887. PMID 18759251. S2CID 44430455.
^"Entrez Gene: CD38 CD38 molecule".
^Jackson DG, Bell JI (April 1990). "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation". Journal of Immunology. 144 (7): 2811–5. doi:10.4049/jimmunol.144.7.2811. PMID 2319135. S2CID 29082806.
^Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, et al. (February 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): 285–92. doi:10.1016/S0378-1119(96)00723-8. PMID 9074508.
^Quarona V, Zaccarello G, Chillemi A (2013). "CD38 and CD157: a long journey from activation markers to multifunctional molecules". Cytometry Part B. 84 (4): 207–217. doi:10.1002/cyto.b.21092. hdl:2318/134656. PMID 23576305. S2CID 205732787.
killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling. In humans, the CD38 protein is encoded by the CD38 gene which...
Darzalex, is an anti-cancer monoclonal antibody medication. It binds to CD38, which is overexpressed in multiple myeloma cells. Daratumumab was originally...
bronchitis (inflammation of the airways in the lungs). Isatuximab is an anti-CD38 mAb intended to treat relapsed or refractory multiple myeloma. It entered...
vulnerable to extracellular degradation by CD38 enzyme, which can be inhibited by compounds such as CD38-IN-78c. NMN is found in fruits and vegetables...
including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The most common adverse reactions include cytokine release...
cells with the greatest self-renewal capacity and were shown to be CD34+ and CD38− cell fraction within the lineage-depleted cell population (LIn−). Human...
cytoplasm and occasionally on the cell surface; myeloma cells are often CD56, CD38, CD138, and CD319 positive and CD19, CD20, and CD45 negative. Flow cytometry...
much weaker catalyst than CD38. cADPR is required for regulation of Ca2+ in cells. Only CD38 hydrolyzed cADPR to ADPR. CD38 is widely expressed in tissues...
including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. The US Food and Drug Administration (FDA) label prescribing...
marrow with an abnormal immunophenotype (CD38+ CD56+ CD19−) mixed in with cells of a normal phenotype (CD38+ CD56− CD19+); in MGUS, on average more than...
ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor. ADPR...
including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. In the EU it is indicated for the treatment of adults...
myeloma who have received at least four prior therapies including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory agent...
Because of the ability to reduce disulfide bonds, DTT can be used to denature CD38 on red blood cells. DTT will also denature antigens in the Kell, Lutheran...
Many markers belong to the cluster of differentiation series, like: CD34, CD38, CD90, CD133, CD105, CD45, and also c-kit – the receptor for stem cell factor...
plasma antibodies, and positively correlated with degranulation of NK cells. CD38 on leukocytes attaching to CD16 on endothelial cells allows for leukocyte...
Candidate genes include OXTR (polymorphisms in the oxytocin receptor), CD38, COMT, DRD4, DRD5, IGF2, AVPR1A and GABRB2. It is theorized that some of...
population often express features of activated CD8+ T cells, such as CD29, CD38, HLA-DR, CD45RO and CD95. Expression of CD25 was on the other hand decreased...
angiogenesis, and integrin activation. CD31 on endothelial cells binds to the CD38 receptor on natural killer cells for those cells to attach to the endothelium...
is now in widespread clinical use. Daratumumab, a monoclonal antibody to CD38, a protein that is expressed on plasma cells, was approved in US and EU for...
the biologist Graham J. Thompson and colleagues identified the genes OXTR, CD38, COMT, DRD4, DRD5, IGF2, GABRB2 as candidates "affecting altruism". The geneticist...
Fradette JJ, Gibbons DL (December 2019). "The Good, the Bad and the Unknown of CD38 in the Metabolic Microenvironment and Immune Cell Functionality of Solid...
proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. In December 2020, selinexor was approved by the FDA...
et al. (July 2015). "Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow". Immunity. 43 (1): 132–45. doi:10...
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