Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[2][3][4][5][6] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[7][8]
Little is known about the pharmacology of dimetacrine,[9] but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
^Kato S (1993). "A Review of the Pharmacotherapy of Depression in Japan". In Kariya T, Nakagawara M (eds.). Affective Disorders: Perspective on Basic Research and Clinical Practice. Tokyo: Seiwa Shoten. ISBN 978-0-87630-674-1.
^Vela JM, Buschmann H, Holenz J, Párraga A, Torrens A (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 978-3-527-31058-6.
^Taen S, Pöldinger W (December 1966). "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]". Schweizerische Medizinische Wochenschrift (in German). 96 (48): 1616–1620. PMID 6008540.
^Meyer R (May 1968). "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]". Praxis (in German). 57 (20): 721–723. PMID 5756370.
^Abuzzahab FS (November 1973). "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology. 8 (3): 244–253. PMID 4149236.
^Mutschler E, Derendorf H (1995). "Psychoactive Drugs: Antidepresants". Drug actions: basic principles and therapeutic aspects. Stuttgart, Germany: Medpharm Scientific Pub. ISBN 0-8493-7774-9. Retrieved January 30, 2013.
^"Dimetacrine". PubChem. U.S. National Library of Medicine. Retrieved 2023-11-03.
Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used...
tolerability and a somewhat faster onset of action. Fluotracen Litracen Dimetacrine Swiss Pharmaceutical Society (2000). Index Nominum 2000: International...
C20H26N2 (molar mass: 294.43 g/mol, exact mass: 294.2096 u) may refer to: Dimetacrine, or acripramine Tetrindole Trimipramine This set index page lists chemical...
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