programmed cell death involved in cell development
apoptotic process
programmed cell death
apoptotic DNA fragmentation
DNA catabolic process, endonucleolytic
neutrophil activation involved in immune response
regulation of acute inflammatory response
regulation of neutrophil mediated cytotoxicity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1776
13421
Ensembl
ENSG00000163687
ENSMUSG00000025279
UniProt
Q13609
O55070
RefSeq (mRNA)
NM_004944 NM_001256560
NM_007870
RefSeq (protein)
NP_001243489 NP_004935
NP_031896
Location (UCSC)
Chr 3: 58.19 – 58.21 Mb
Chr 14: 14.48 – 14.51 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.[5][6][7][8]
This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[8]
Homozygosity for a null allele results in systemic lupus erythematosus.[9] A loss of function allele in DNASE1L3 is associated with rheumatoid arthritis.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000163687 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025279 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (June 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
^Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (July 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
^Shiokawa D, Hirai M, Tanuma S (March 1998). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. S2CID 2071259.
^Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, et al. (October 2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–8. doi:10.1038/ng.975. PMID 22019780. S2CID 205358301.
^Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, et al. (October 2018). "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes". Nature Genetics. 50 (10): 1366–1374. doi:10.1038/s41588-018-0216-7. PMC 6364548. PMID 30224649.
Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene. This gene encodes a member of the DNase family. The protein hydrolyzes...
is DNase I. This family consisted of DNase I, DNase1L1, DNase 1L2, and DNase1L3. DNase I cleaves DNA to form two oligonucleotide-end products with 5’-phospho...