Chemical compound
Decernotinib
(2R )-2-Methyl-2-[[2-(1H -pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N -(2,2,2-trifluoroethyl)butanamide
CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard (EPA ) DTXSID70241504 Formula C 18 H 19 F 3 N 6 O Molar mass 392.386 g·mol−1 3D model (JSmol)
CC[C@](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3
InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1
Key:ASUGUQWIHMTFJL-QGZVFWFLSA-N
Decernotinib is an inhibitor of Janus kinase 3 (JAK3) discovered through a process of inhouse screening of a chemical compound library. Decernotinib also had the name VX-509 in development phase. It is an experimental drug with high selectivity for JAK3, which demonstrates good efficacy in vivo in the rat host versus graft model (HvG). It is being studied in clinical trials at Vertex.[1]
^ Farmer LJ, Ledeboer MW, Hoock T, Arnost MJ, Bethiel RS, Bennani YL, et al. (September 2015). "Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases". Journal of Medicinal Chemistry . 58 (18): 7195–216. doi:10.1021/acs.jmedchem.5b00301. PMID 26230873.
Last Update: 2021-03-25T10:39:32Z
Decernotinib is an inhibitor of Janus kinase 3 (JAK3) discovered through a process of inhouse screening of a chemical compound library. Decernotinib also...
Word Count : 118
Last Update: 2024-03-21T22:16:34Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 3413
Last Update: 2024-05-15T12:02:25Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 3857
Last Update: 2024-05-24T13:29:17Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 664
Last Update: 2024-05-23T09:06:58Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2160
Last Update: 2024-04-11T17:43:27Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 7054
Last Update: 2024-04-02T02:10:23Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2090
Last Update: 2024-04-27T07:08:48Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 443
Last Update: 2024-05-09T16:20:02Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2858
Last Update: 2024-04-01T06:57:58Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 4534
Last Update: 2024-04-08T01:05:03Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2088
Last Update: 2024-02-08T04:13:59Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 3189
Last Update: 2024-05-20T07:30:05Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 3686
Last Update: 2024-04-13T04:27:34Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2882
Last Update: 2024-05-09T13:45:38Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 1384
Last Update: 2024-02-15T05:25:09Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2932
Last Update: 2024-05-16T06:53:21Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2264
Last Update: 2024-04-23T21:00:39Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 654
Last Update: 2024-03-26T05:49:17Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 1645
Last Update: 2024-01-14T12:50:57Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 1124
Last Update: 2024-02-02T19:47:03Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 1415
Last Update: 2024-03-14T10:58:28Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 974
Last Update: 2024-05-16T17:29:11Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 521
Last Update: 2024-01-26T21:26:11Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 2727
Last Update: 2024-05-28T04:42:09Z
Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib) JAK3 Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib)...
Word Count : 694