Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count.[13] Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause.[13] It may also be used to increase white blood cells for gathering during leukapheresis.[13] It is given either by injection into a vein or under the skin.[13] Filgrastim is a leukocyte growth factor.[12]
Common side effects include fever, cough, chest pain, joint pain, vomiting, and hair loss.[13] Severe side effects include splenic rupture and allergic reactions.[13] It is unclear if use in pregnancy is safe for the baby.[13] Filgrastim is a recombinant form of the naturally occurring granulocyte colony-stimulating factor (G-CSF).[13] It works by stimulating the body to increase neutrophil production.[13]
Filgrastim was approved for medical use in the United States in 1991.[13] It is on the World Health Organization's List of Essential Medicines.[14][15] Filgrastim biosimilar medications are available.[13]
^ abCite error: The named reference Nivestim EPAR was invoked but never defined (see the help page).
^Cite error: The named reference Nivestym SBD was invoked but never defined (see the help page).
^Cite error: The named reference Nypozi SBD was invoked but never defined (see the help page).
^ ab"Releuko- filgrastim injection, solution". DailyMed. 11 March 2022. Archived from the original on 17 March 2022. Retrieved 16 March 2022.
^Cite error: The named reference FDA_Zarxio_2015 was invoked but never defined (see the help page).
^ abCite error: The named reference Zarzio EPAR was invoked but never defined (see the help page).
^"Filgrastim Use During Pregnancy". Drugs.com. 13 September 2018. Archived from the original on 18 December 2019. Retrieved 17 December 2019.
^"Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
^"Neupogen 30 MU (0.3 mg/ml) solution for injection - Summary of Product Characteristics (SmPC)". (emc). 7 May 2021. Archived from the original on 1 March 2022. Retrieved 1 March 2022.
^"Zarzio 30 MU/0.5 ml solution for injection or infusion in pre-filled syringe - Summary of Product Characteristics (SmPC)". (emc). 4 July 2019. Archived from the original on 20 December 2019. Retrieved 20 December 2019.
^"Nivestim 12 MU/ 0.2 ml solution for injection/infusion - Summary of Product Characteristics (SmPC)". (emc). 18 December 2019. Archived from the original on 20 December 2019. Retrieved 20 December 2019.
^ abCite error: The named reference Neupogen FDA label was invoked but never defined (see the help page).
^ abcdefghijk"Filgrastim". The American Society of Health-System Pharmacists. Archived from the original on 10 May 2017. Retrieved 8 December 2016.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. Low neutrophil counts may occur with HIV/AIDS...
recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the production of white blood cells (neutrophils)...
the United States' first biosimilar product, the biosimilar of filgrastim called filgrastim-sndz (trade name Zarxio) by Sandoz. In the United States, the...
December 2006, to seek approval for a clinical trial of its biosimilar Filgrastim in Europe and was certified as EU-GMP compliant in April 2007, becoming...
way to boost white blood count. Apotex's version is known as Grastofil (filgrastim) and is licensed for sale in Europe by Stada Arzneimittel. In February...
long-term use of filgrastim causing sequestration of platelets in the spleen in GSD Ib, anemia, due to long-term use of filgrastim causing sequestration...
occurring glycoproteins that stimulate white blood cell proliferation. Filgrastim is a synthetic form of GCSF produced in E.coli. PBSC donors are given...
guidelines. Company has developed biosimilar versions of Etanercept, Filgrastim, Peg-filgrastim, Ranibizumab. Lupin forayed into diagnostics business in December...
receiving chemotherapy. Lipegfilgrastim is a filgrastim biosimilar. In lipegfilgrastim, the filgrastim has been 'pegylated' (attached to polyethylene...
subcutaneous (SC) injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation...
factor used (G-CSF). G-CSF drugs include filgrastim (Neupogen, Neulasta), and lenograstim (Graslopin). Filgrastim is typically dosed in the 10 microgram/kg...
States in September 2023. Motixafortide is indicated, in combination with filgrastim, a granulocyte-colony stimulating factor (G-CSF), to mobilize hematopoietic...
(neutropenia) can cause complications, and is sometimes treated with drugs like filgrastim. The most notable complication of neutropenia is increased probability...
improved with synthetic G-CSF (granulocyte-colony-stimulating factor, e.g., filgrastim, lenograstim, efbemalenograstim alfa). In very severe myelosuppression...
has obtained a marketing authorization in 2016 for the biosimilar of Filgrastim, marketed under Fraven, which is the first biosimilar drug, developed...
kill the hairy cells. People with low neutrophil counts may be given filgrastim or a similar hormone to stimulate production of white blood cells. However...
Announces FDA Approval of Aphexda (motixafortide) in Combination with Filgrastim (G-CSF) to Mobilize Hematopoietic Stem Cells for Collection and Subsequent...
comparison of efficacy of sargramostim (yeast-derived RhuGM-CSF) and filgrastim (bacteria-derived RhuG-CSF) in the therapeutic setting of chemotherapy-induced...
PMID 17209059. Saven A, Burian C, Adusumalli J, Koziol JA (April 1999). "Filgrastim for cladribine-induced neutropenic fever in patients with hairy cell leukemia"...
in chronic neutropenia. Recombinant G-CSF factor preparations, such as filgrastim can be effective in people with congenital forms of neutropenia including...
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