structure of the FADD (Mort1) death-effector domain.[1]
Identifiers
Symbol
DED
Pfam
PF01335
InterPro
IPR001875
SMART
DED
PROSITE
PS50168
SCOP2
1a1z / SCOPe / SUPFAM
CDD
cd00045
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
PDB
1a1w, 1a1z, 1e3y, 1e41, 1n3k, 2gf5
The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways.[2] The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). This recruitment is mediated by a homotypic interaction between the procaspase DED and a second DED that is death effector domain in an adaptor protein that is directly associated with activated TNF receptors. Complex formation allows proteolytic activation of procaspase into the active caspase form which results in the initiation of apoptosis (cell death). Structurally the DED domain are a subclass of protein motif known as the death fold and contains 6 alpha helices, that closely resemble the structure of the Death domain (DD).
^Eberstadt M, Huang B, Chen Z, et al. (April 1998). "NMR structure and mutagenesis of the FADD (Mort1) death-effector domain". Nature. 392 (6679): 941–5. Bibcode:1998Natur.392..941E. doi:10.1038/31972. PMID 9582077. S2CID 4370202.
The death-effectordomain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways. The...
involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like deatheffectordomain of this protein suggests that...
is related in sequence and structure to the deatheffectordomain (DED) and the caspase recruitment domain (CARD), which work in similar pathways and show...
acids. It contains two main domains: a C terminal deathdomain (DD) and an N terminal deatheffectordomain (DED). Each domain, although sharing very little...
include the deathdomain (DD), deatheffectordomain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD). Death fold domains are an evolutionarily...
Deatheffectordomain containing protein is a protein that in humans is encoded by the DEDD gene. This gene encodes a protein that contains a death effector...
adaptor molecule FADD to bind the deathdomain of Fas through its own deathdomain. FADD also contains a deatheffectordomain (DED) near its amino terminus...
Cadherin domains are extracellular regions which mediate cell-to-cell homophilic binding between cadherins on the surface of adjacent cells. Deatheffector domain...
Fas-associated deathdomain (FADD) to bind the deathdomain (DD) of Fas through its own deathdomain (DD). FADD also contains a deatheffectordomain (DED) near...
Zheng L, Schickling O, Peter M E, Lenardo M J (August 2001). "The deatheffectordomain-associated factor plays distinct regulatory roles in the nucleus...
PMID 8943360. Zheng L, Schickling O, Peter ME, Lenardo MJ (Aug 2001). "The deatheffectordomain-associated factor plays distinct regulatory roles in the nucleus...
The public domain (PD) consists of all the creative work to which no exclusive intellectual property rights apply. Those rights may have expired, been...
ded in Wiktionary, the free dictionary. Ded or DED may refer to: Deatheffectordomain, a signalling pathway in cell biology Diabetic eye disease, also...
recruitment domain (CARD), while the pro-domain of the extrinsic initiator caspases contains two death folds known as deatheffectordomains (DED). Multiprotein...
(September 2002). "Regulation of Fas-associated deathdomain interactions by the deatheffectordomain identified by a modified reverse two-hybrid screen"...
(October 1997). "MRIT, a novel death-effectordomain-containing protein, interacts with caspases and BclXL and initiates cell death". Proceedings of the National...
SCC-S2, containing the consensus sequence of a deatheffectordomain of fas-associated deathdomain-like interleukin- 1beta-converting enzyme-inhibitory...
Works are in the public domain if they are not covered by the intellectual property right known as copyright, or if the intellectual property rights to...
Domain fronting is a technique for Internet censorship circumvention that uses different domain names in different communication layers of an HTTPS connection...
triggered by the polarising cytokine IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of Th1 immunity are macrophages as well as...
crystallization and preliminary crystallographic analysis of pseudo death-effectordomain of HIPPI, a molecular partner of Huntingtin-interacting protein...
Global Information