Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3.
CASP8 orthologs[5] have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.
^ abcGRCh38: Ensembl release 89: ENSG00000064012 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026029 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"OrthoMaM phylogenetic marker: CASP8 coding sequence".[permanent dead link]
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
caspase-8 but lacking enzymatic activity, plays a dual role in Fas-induced apoptosis. At low concentrations, c-FLIP is believed to promote caspase-8 activation...
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive...
the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. In...
heterotetramer enzyme. Active caspase-8 is then released from the DISC into the cytosol, where it cleaves other effector caspases, eventually leading to DNA...
regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase...
Activated caspase8 cleaves these kinases, inhibiting necroptosis. Since activation of caspase8 requires FADD in order to bring the procaspase 8 molecules...
worked out the complex molecular mechanisms that regulate activity of caspase-8, OTULIN, RIPK1, RIPK3 and other proteins that modulate inflammation, apoptosis...
mutated or improperly regulated. Many of these inhibitors act to block caspases, a family of cysteine proteases that play an integral role in apoptosis...
cysteine protease caspase-8. A high concentration of caspase-8 induces its autoproteolytic activation and subsequent cleaving of effector caspases, leading to...
defective for FADD and the I 9.2 cell line is functionally defective for caspase-8, both defective molecules being essential to apoptosis or necroptosis...
three distinct isoforms. Caspase 7 has been shown to interact with: Caspase8, Survivin and XIAP. The Proteolysis Map Caspase GRCh38: Ensembl release 89:...
a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains...
then binds to caspase-8, forming a caspase-8 FLIP heterodimer in the cytosol that disrupts the activity of caspase-8 and prevents caspase-8 mediated apoptosis...
dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase8 and caspase 10 in vitro, and by anti-Fas agonist...
November 2005). "Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells"...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
TNFα signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis. Recent studies have reported...
Wikholm; et al. (February 18, 2003). "kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms". Proc Natl Acad...
epithelial cell death via apoptosis and necrosis. ECP triggers apoptosis by caspase-8 activation through mitochondria-independent pathway. Increases in chromatin...
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