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Death Domain Database
Content
Description
protein-protein interaction database for the Death Domain superfamily.
Contact
Authors
Dongseop Kwon
Primary citation
Kwon & al. (2012)[1]
Release date
2011
Access
Website
www.deathdomain.org
The Death Domain database is a secondary database of protein-protein interactions (PPI) of the death domain superfamily.[1] Members of this superfamily are key players in apoptosis, inflammation, necrosis, and immune cell signaling pathways. Negative death domain superfamily-mediated signaling events result in various human diseases which include, cancers, neurodegenerative diseases, and immunological disorders. Creating death domain databases are of particular interest to researchers in the biomedical field as it enables a further understanding of the molecular mechanisms involved in death domain interactions while also providing easy access to tools such as an interaction map that illustrates the protein-protein interaction network and information. There is currently only one database that exclusively looks at death domains but there are other databases and resources that have information on this superfamily.[1] According to PubMed,[2] this database has been cited by seven peer-reviewed articles to date because of its extensive and specific information on the death domains and their PPI summaries.
^ abcKwon, Dongseop; Yoon Jong Hwan; Shin Soo-Yong; Jang Tae-Ho; Kim Hong-Gee; So Insuk; Jeon Ju-Hong; Park Hyun Ho (Jan 2012). "A comprehensive manually curated protein-protein interaction database for the Death Domain superfamily". Nucleic Acids Research. 40 (D1): D331–D336. doi:10.1093/nar/gkr1149. PMC 3245059. PMID 22135292.
^Cite error: The named reference PubMed was invoked but never defined (see the help page).
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