positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
cellular response to mechanical stimulus
circadian rhythm
apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
spleen development
negative thymic T cell selection
regulation of lymphocyte differentiation
necroptotic signaling pathway
motor neuron apoptotic process
inflammatory response
regulation of myeloid cell differentiation
protein homooligomerization
response to toxic substance
B cell mediated immunity
neuron apoptotic process
positive regulation of protein homooligomerization
cellular response to lithium ion
positive regulation of lymphocyte apoptotic process
negative regulation of apoptotic process
immune response
gene expression
cellular response to hyperoxia
negative regulation of B cell activation
response to glucocorticoid
extrinsic apoptotic signaling pathway in absence of ligand
inflammatory cell apoptotic process
immunoglobulin production
signal transduction
hepatocyte apoptotic process
response to lipopolysaccharide
extrinsic apoptotic signaling pathway
regulation of apoptotic process
positive regulation of apoptotic process
regulation of cell population proliferation
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
multicellular organism development
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of protein phosphorylation
regulation of stress-activated MAPK cascade
cellular response to amino acid starvation
Fas signaling pathway
positive regulation of apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
355
14102
Ensembl
ENSG00000026103
ENSMUSG00000024778
UniProt
P25445
P25446
RefSeq (mRNA)
NM_000043 NM_152871 NM_152872 NM_152873 NM_152874
NM_152875 NM_152876 NM_152877 NM_001320619
NM_001146708 NM_007987
RefSeq (protein)
NP_000034 NP_001307548 NP_690610 NP_690611
NP_001140180 NP_032013
Location (UCSC)
Chr 10: 88.95 – 89.03 Mb
Chr 19: 34.29 – 34.33 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.[5][6] Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.[7]
The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis) if it binds its ligand, Fas ligand (FasL). It is one of two apoptosis pathways, the other being the mitochondrial pathway.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000026103 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024778 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19". Genomics. 14 (1): 179–80. doi:10.1016/S0888-7543(05)80302-7. PMID 1385299.
^Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics. 14 (3): 821–2. doi:10.1016/S0888-7543(05)80200-9. PMID 1385309.
^Nagata S (July 2004). "Early work on the function of CD95, an interview with Shige Nagata". Cell Death and Differentiation. 11 (Suppl 1): S23-7. doi:10.1038/sj.cdd.4401453. PMID 15143352.
^Wajant H (May 2002). "The Fas signaling pathway: more than a paradigm". Science. 296 (5573): 1635–6. Bibcode:2002Sci...296.1635W. doi:10.1126/science.1071553. PMID 12040174. S2CID 29449108.
The Fasreceptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily...
endothelial cells and natural killer (NK) cells. It binds with its receptor, called FASreceptor (also called CD95) and plays a crucial role in the regulation...
antigen leads to coexpression of Fas and Fasreceptor on the T cell surface. The engagement of Fas by Fasreceptor results in apoptosis of the cell and...
membrane-bound form of the Fasreceptor, which promotes apoptosis, or programmed cell death. Increased expression of Fasreceptor in skin cells chronically...
Look up FAS, Fas, or fas in Wiktionary, the free dictionary. Fas or FAS may refer to: Fez, Morocco, alternate spelling Poti, Georgia, a port city in Georgia...
protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing...
uncontrolled cell proliferation, such as cancer. Some factors like Fasreceptors and caspases promote apoptosis, while some members of the Bcl-2 family...
that is bound to the Fas gene promoter in T cells, resulting in hyperacetylation of the Fas promoter and up-regulation of Fasreceptor on the T-cell surface...
M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis. Dcr3 was identified in 1998 by...
progenitor cells and lymphocytes in the bone marrow over-express the Fasreceptor, the main element in apoptotic signaling. A significant increase in the...
factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that...
However Accutase decreases the surface levels of FasL and Fasreceptor on macrophages, these receptors are associated with cell cytotoxicity in the immune...
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it...
interaction of Fasreceptor (Fas, CD95)and Fas ligand (FasL, CD95 ligand). It occurs as a result of repeated stimulation of specific T-cell receptors (TCR) and...
2002). "Caspase-dependent initiation of apoptosis and necrosis by the Fasreceptor in lymphoid cells: onset of necrosis is associated with delayed ceramide...
part of the body. FAS/FAS-L system – expression of Fas ligand (Fas-L) on the surface of SCs activates apoptotic death of Fasreceptor-bearing cells, e...
CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one...
gene defect, and autoimmune lymphoproliferative syndrome (defective Fasreceptor gene). More than 30 other primary immunodeficiency diseases are sometimes...
Additionally, EpoR has been implicated in suppressing expression of death receptorsFas, Trail and TNFa that negatively affect erythropoiesis. Based on current...
Cytokine receptors are receptors that bind to cytokines. In recent years, the cytokine receptors have come to demand the attention of more investigators...
expression of tumor suppressor genes such as p53, BRCA1, BRCA2, RB1, or the fasreceptor. A tumor suppressor would trigger an apoptotic pathway in a cancer cell...
Global Information
