Cry6Aa (Pesticidal crystal protein Cry6Aa) is a toxic crystal protein generated by the bacterial family Bacillus thuringiensis during sporulation.[1] This protein is a member of the alpha pore forming toxins family, which gives it insecticidal qualities advantageous in agricultural pest control. Each Cry protein has some level of target specificity; Cry6Aa has specific toxic action against coleopteran insects and nematodes. The corresponding B. thuringiensis gene, cry6aa, is located on bacterial plasmids. Along with several other Cry protein genes, cry6aa can be genetically recombined in Bt corn and Bt cotton so the plants produce specific toxins. Insects are developing resistance to the most commonly inserted proteins like Cry1Ac.[2] Since Cry6Aa proteins function differently than other Cry proteins, they are combined with other proteins to decrease the development of pest resistance. Recent studies suggest this protein functions better in combination with other virulence factors such as other Cry proteins and metalloproteinases.[3]>[4]
^Adang MJ, Crickmore N, Jurat-Fuentes JL (January 2014). "Diversity of Bacillus thuringiensis crystal toxins and mechanism of action.". Advances in insect physiology. Vol. 47. Academic Press. pp. 39–87. doi:10.1016/B978-0-12-800197-4.00002-6. ISBN 9780128001974.
^Tabashnik BE, Brévault T, Carrière Y (June 2013). "Insect resistance to Bt crops: lessons from the first billion acres". Nature Biotechnology. 31 (6): 510–21. doi:10.1038/nbt.2597. PMID 23752438. S2CID 205278530.
^Peng D, Chai L, Wang F, Zhang F, Ruan L, Sun M (November 2011). "Synergistic activity between Bacillus thuringiensis Cry6Aa and Cry55Aa toxins against Meloidogyne incognita". Microbial Biotechnology. 4 (6): 794–8. doi:10.1111/j.1751-7915.2011.00295.x. PMC 3815414. PMID 21923640.
^Luo X, Chen L, Huang Q, Zheng J, Zhou W, Peng D, Ruan L, Sun M (January 2013). "Bacillus thuringiensis metalloproteinase Bmp1 functions as a nematicidal virulence factor". Applied and Environmental Microbiology. 79 (2): 460–8. Bibcode:2013ApEnM..79..460L. doi:10.1128/AEM.02551-12. PMC 3553750. PMID 23124228.
Cry6Aa (Pesticidal crystal protein Cry6Aa) is a toxic crystal protein generated by the bacterial family Bacillus thuringiensis during sporulation. This...
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