Clevidipine information

Clevidipine
Clinical data
Trade names	Cleviprex
AHFS/Drugs.com	Monograph
License data	US DailyMed: Clevidipine;
Routes of; administration	Intravenous
ATC code	C08CA16 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	100% (used only IV)
Protein binding	>99.5%
Metabolism	Blood and tissue esterases
Elimination half-life	1 minute
Excretion	Urine (63–74%), feces (7–22%)
Identifiers
	IUPAC name (RS)-5-O-(Butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
CAS Number	167221-71-8 ;
PubChem CID	153994;
ChemSpider	135722;
UNII	19O2GP3B7Q;
ChEMBL	ChEMBL1237132;
CompTox Dashboard (EPA)	DTXSID6057661 ;
ECHA InfoCard	100.208.117
Chemical and physical data
Formula	C21H23Cl2NO6
Molar mass	456.32 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(OCOC(=O)CCC)\C1=C(\N/C(=C(/C(=O)OC)[C@H]1c2cccc(Cl)c2Cl)C)C;

Clevidipine (INN,^[2] trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower blood pressure. It has a half-life of approximately one minute. It is rapidly inactivated by esterases.

It was approved by the United States Food and Drug Administration on August 1, 2008.

^ https://www.ema.europa.eu/documents/psusa/clevidipine-list-nationally-authorised-medicinal-products-psusa/00010288/202005_en.pdf ^{[bare URL PDF]}
^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 37" (PDF). World Health Organization. 1997. p. 37. Retrieved 24 November 2016.

[1] ttps://www.ema.europa.eu/documents/psusa/clevidipine-list-nationally-authorised-medicinal-products-psusa/00010288/202005_en.pdf ^{[bare URL PDF]}

[INN-2] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 37" (PDF). World Health Organization. 1997. p. 37. Retrieved 24 November 2016.

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