Dihydropyridine calcium channel blockers information
A class of medication used to treat high blood pressure
Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers.[1] They are used in the treatment of hypertension.[2]
Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel walls.[3]
^Bladen, Chris; Gündüz, Miyase Gözde; Şimşek, Rahime; Şafak, Cihat; Zamponi, Gerald W. (2014-10-23). "Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity". Pflügers Archiv: European Journal of Physiology. 466 (7): 1355–1363. doi:10.1007/s00424-013-1376-z. ISSN 1432-2013. PMID 24149495. S2CID 253888496.
^Frishman, William H. (2007). "Calcium channel blockers: differences between subclasses". American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 7 (Suppl 1): 17–23. doi:10.2165/00129784-200707001-00003. ISSN 1175-3277. PMID 19845073. S2CID 21199295.
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