Steps in nucleosome assembly. CAF-1 is shown in yellow interacting with the H3-H4 tetramer.
Chromatin assembly factor-1 (CAF-1) is a protein complex — including Chaf1a (p150), Chaf1b (p60), and p48 subunits in humans, or Cac1, Cac2, and Cac3, respectively, in yeast— that assembles histone tetramers onto replicating DNA during the S phase of the cell cycle.[1][2][3][4]
^Fang, Dong; Han, Junhong (2020-11-06). Histone Mutations and Cancer. Springer Nature. ISBN 978-981-15-8104-5.
^Smith S, Stillman B (July 1989). "Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro". Cell. 58 (1): 15–25. doi:10.1016/0092-8674(89)90398-X. PMID 2546672. S2CID 10515064.
^Hoek M, Stillman B (October 2003). "Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12183–12188. Bibcode:2003PNAS..10012183H. doi:10.1073/pnas.1635158100. PMC 218733. PMID 14519857.
^Volk, Andrew; Crispino, John D. (August 2015). "The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849 (8): 979–986. doi:10.1016/j.bbagrm.2015.05.009. ISSN 0006-3002. PMC 4515380. PMID 26066981.
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