CHAF1B information

CHAF1B
Identifiers
Aliases	CHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7, chromatin assembly factor 1 subunit B
External IDs	OMIM: 601245; MGI: 1314881; HomoloGene: 48346; GeneCards: CHAF1B; OMA:CHAF1B - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,419,015 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,703,003 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gastrocnemius muscle; ; muscle of thigh; ; ventricular zone; ; ganglionic eminence; ; buccal mucosa cell; ; testicle; ; stromal cell of endometrium; ; gonad; ; skeletal muscle tissue;
	Top expressed in
	embryo; ; epiblast; ; genital tubercle; ; primitive streak; ; tail of embryo; ; embryo; ; abdominal wall; ; ventricular zone; ; morula; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; histone binding; chromatin binding; protein binding;
Cellular component	cytoplasm; cytosol; CAF-1 complex; nucleoplasm; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to DNA damage stimulus; DNA replication-dependent chromatin assembly; DNA replication; cell cycle; DNA repair; nucleosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	8208
	110749
	ENSG00000159259
	ENSMUSG00000022945
	Q13112
	Q9D0N7
	NM_005441
	NM_028083
	NP_005432
	NP_082359
	Wikidata
View/Edit Human	View/Edit Mouse

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022945 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaufman PD, Kobayashi R, Kessler N, Stillman B (Jun 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. S2CID 13502921.
^ Katsanis N, Fisher EM (Oct 1996). "The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome". Human Genetics. 98 (4): 497–9. doi:10.1007/s004390050246. PMID 8792829. S2CID 1206979.
^ "Entrez Gene: CHAF1B chromatin assembly factor 1, subunit B (p60)".

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