TOP3A information

TOP3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CGY, 4CHT
Identifiers
Aliases	TOP3A, TOP3, ZGRF7, topoisomerase (DNA) III alpha, DNA topoisomerase III alpha, PEOB5, MGRISCE2
External IDs	OMIM: 601243; MGI: 1197527; HomoloGene: 3394; GeneCards: TOP3A; OMA:TOP3A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,315,007 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,668,191 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; bone marrow cells; ; monocyte; ; stromal cell of endometrium; ; thymus; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; muscle tissue;
	Top expressed in
	spermatocyte; ; secondary oocyte; ; spermatid; ; seminiferous tubule; ; yolk sac; ; thymus; ; maxillary prominence; ; morula; ; somite; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA topoisomerase type I (single strand cut, ATP-independent) activity; DNA binding; zinc ion binding; protein binding; isomerase activity; metal ion binding; DNA topoisomerase activity; single-stranded DNA binding; nucleic acid binding;
Cellular component	PML body; nucleoplasm; chromosome; nucleus; mitochondrion; mitochondrial matrix;
Biological process	DNA replication; DNA topological change; meiosis; mitochondrial DNA metabolic process; chromosome separation; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	7156
	21975
	ENSG00000284238; ENSG00000177302
	ENSMUSG00000002814
	Q13472
	O70157
	NM_004618; NM_001320759
	NM_009410
	NP_001307688; NP_004609
	NP_033436
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene.^[5]^[6]

^ ^a ^b ^c ENSG00000177302 GRCh38: Ensembl release 89: ENSG00000284238, ENSG00000177302 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002814 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Elsea SH, Fritz E, Schoener-Scott R, Meyn MS, Patel PI (Jan 1998). "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity". American Journal of Medical Genetics. 75 (1): 104–8. doi:10.1002/(SICI)1096-8628(19980106)75:1<104::AID-AJMG21>3.0.CO;2-P. PMID 9450867.
^ "Entrez Gene: TOP3A topoisomerase (DNA) III alpha".

[refGRCh38Ensembl-1] ENSG00000177302 GRCh38: Ensembl release 89: ENSG00000284238, ENSG00000177302 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002814 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9450867-5] Elsea SH, Fritz E, Schoener-Scott R, Meyn MS, Patel PI (Jan 1998). "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity". American Journal of Medical Genetics. 75 (1): 104–8. doi:10.1002/(SICI)1096-8628(19980106)75:1<104::AID-AJMG21>3.0.CO;2-P. PMID 9450867.

[entrez-6] "Entrez Gene: TOP3A topoisomerase (DNA) III alpha".

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