Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene.[5][6][7] The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9me3 is a repressive modification.
^ abcGRCh38: Ensembl release 89: ENSG00000141644 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024561 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cross SH, Meehan RR, Nan X, Bird A (Jul 1997). "A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins". Nat Genet. 16 (3): 256–9. doi:10.1038/ng0797-256. PMID 9207790. S2CID 23475072.
^Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (Sep 1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm Genome. 10 (9): 906–12. doi:10.1007/s003359901112. PMID 10441743. S2CID 819148.
^"Entrez Gene: MBD1 methyl-CpG binding domain protein 1".
protein 1 is a protein that in humans is encoded by the MBD1 gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences...
protein 1, MBD1, upstream and myosin VB3, MYO5B, downstream. All CCDC11, MBD1 and MYO5B are oriented negatively. Note the close proximity between MBD1 and CCDC11...
histone lysine methylation. For instance, the methyl binding domain protein MBD1, attracted to and associating with methylated cytosine in a DNA CpG site...
ENSG00000103495 C2H2 ZF Known motif – High-throughput in vitro [508] GGGMGGGGS MBD1 ENSG00000141644 MBD; CxxC ZF Likely sequence specific TF according to literature...
humans is encoded by the ATF7IP gene. ATF7IP has been shown to interact with MBD1. In mice with T cell-specific deletion of Atf7ip, the protein has been shown...
through interaction with methyl binding domain (MBD) proteins, such as MeCP2, MBD1 and MBD2. These MBD proteins bind most strongly to highly methylated CpG...
through interaction with methyl binding domain (MBD) proteins, such as MeCP2, MBD1 and MBD2. These MBD proteins bind most strongly to highly methylated CpG...
silenced chromatin thanks to interaction with molecular complex ATF7ip- MBD1 which binds methylated CpG di-nucleotides. After the recognition of Aire...
PKP Class UIC class Quantity Manufacturer Year(s) Gauge Notes MBd1 various 19 various 1933–1971 750 mm MBxd1 various 16+19 various 1930–1967 750 mm, 1000 mm...
PMID 15231748. Sarraf SA, Stancheva I (2004). "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and...
plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 (this gene) comprise a family of nuclear proteins related...
OMIM] CHAF1A has been shown to interact with: ASF1A, ASF1B, BLM, CBX5, and MBD1. GRCh38: Ensembl release 89: ENSG00000167670 – Ensembl, May 2017 GRCm38:...
MBD1, Numbl, and miR-184 all work together to regulate the proliferation and differentiation of aNSCs. In addition, miR-195 works closely with MBD1 to...
plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the...
Chiquet-Ehrismann R (April 2005). "The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation...
methyltransferase EHMT2, heterochromatin protein 1 (HP1 alpha, HP1 beta, HP1 gamma), MBD1, TRIM28 and CDYL as partners of BAHD1. Overexpression of BAHD1 in HEK293...
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