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Chinese hamster ovary cell information


CHO cells adhered to a surface, seen under phase-contrast microscopy

Chinese hamster ovary (CHO) cells are a family of immortalized cell lines[1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.[1][2] They have found wide use in studies of genetics, toxicity screening, nutrition and gene expression, and particularly since the 1980s to express recombinant proteins. CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics.[2]

  1. ^ a b Eberle, Christian (3 May 2022). "CHO cells – 7 facts about the cell line derived from the ovary of the Chinese hamster". evitria. Retrieved 30 January 2024.
  2. ^ a b Cite error: The named reference Wurm2004 was invoked but never defined (see the help page).

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Chinese hamster ovary cell

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Organization's List of Essential Medicines. It is made using Chinese hamster ovary cells. Nivolumab is the second FDA-approved systemic therapy for mesothelioma...

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immunotherapy -- CAR T cell -- Cell therapy -- Chemogenomics -- Chimera (genetics) -- Chinese hamster -- Chinese Hamster Ovary cell -- Chiron Corp. -- Cloning...

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produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown...

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systems are Chinese Hamster ovary (CHO) and Human embryonic kidney (HEK) cells. Chinese hamster ovary cell Mouse myeloma lymphoblstoid (e.g. NS0 cell) Fully...

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genotype of each individual. In cultured mammalian cells, such as the Chinese hamster ovary cell line, a number of genetic loci are present in a functional...

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example, researchers were able to overexpress transporter genes in hamster ovary cells to increase monoclonal antibody yield. Another approach could involve...

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Relatlimab

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under development by Bristol-Myers Squibb. It is made using Chinese hamster ovary cells. As of 2018[update], relatlimab is undergoing Phase II/III trials...

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Dornase alfa

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promoting improved clearance of secretions. It is produced in Chinese hamster ovary cells. Dornase alfa is indicated for the management of people with...

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Biotechnology in pharmaceutical manufacturing

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were inserted into Chinese hamster ovary cells via transfection. Transfection involves the insertion of DNA into a eukaryotic cell. Unlike the analogous...

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intellectual property in CRISPR with Horizon's expertise in Chinese hamster ovary cells. Perkin-Elmer acquired Horizon Discovery for $383 million (£296...

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"Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR". British Journal of Pharmacology. 128 (1): 1–3...

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Tenecteplase

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recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed...

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Kojic acid

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cancer cells (HeLa) and human colon cancer cells (Caco-2) in comparison with quercetin itself. Kojic acid has been shown to protect Chinese hamster ovary cells...

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Pozelimab

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inhibitor. It is produced using recombinant DNA technology in Chinese hamster ovary cells. The most common adverse reactions include upper respiratory...

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Ketamine

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recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells". Anesthesiology. 90 (1): 174–82. doi:10.1097/00000542-199901000-00023...

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PEX14

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peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal...

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Podophyllotoxin

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Gupta R (January 1982). "Podophyllotoxin-resistant mutants of Chinese hamster ovary cells. Alteration in a microtubule-associated protein". The Journal...

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Efflux pump

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1976). "A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants". Biochimica et Biophysica Acta (BBA) - Biomembranes....

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Glycogen storage disease type II

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biologically active recombinant human alglucosidase alfa produced in Chinese Hamster Ovary cells. Myozyme falls under the FDA orphan drug designation and was...

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Emetine

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molecular basis of emetine resistance in Chinese hamster ovary cells: alteration in the 40S ribosomal subunit". Cell. 10 (1): 61–6. doi:10.1016/0092-8674(77)90140-4...

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intellectual property in CRISPR with Horizon's expertise in Chinese hamster ovary cells. Also in 2020, both Mammoth Biosciences and Sherlock Biosciences...

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Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. After...

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"Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism...

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Fucose

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diphosphoglucose: fucose-[beta]1,3-glucosyltransferase activity from Chinese hamster ovary cells". Glycobiology. 9 (7): 679–687. doi:10.1093/glycob/9.7.679. PMID 10362837...

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