Chinese hamster ovary (CHO) cells are a family of immortalized cell lines[1] derived from epithelial cells of the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of recombinant therapeutic proteins.[1][2] They have found wide use in studies of genetics, toxicity screening, nutrition and gene expression, and particularly since the 1980s to express recombinant proteins. CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics.[2]
^ abEberle, Christian (3 May 2022). "CHO cells – 7 facts about the cell line derived from the ovary of the Chinese hamster". evitria. Retrieved 30 January 2024.
^ abCite error: The named reference Wurm2004 was invoked but never defined (see the help page).
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Chinesehamsterovary (CHO) cells are a family of immortalized cell lines derived from epithelial cells of the ovary of the Chinesehamster, often used...
The Chinese dwarf hamster is the animal of choice featured in the speculative evolution project Hamster's Paradise. ChinesehamsterovarycellChinese Striped...
Organization's List of Essential Medicines. It is made using Chinesehamsterovarycells. Nivolumab is the second FDA-approved systemic therapy for mesothelioma...
obscurus"—Chinese striped hamster, also called Chinesehamster; striped dwarf hamster Species C. griseus—Chinese (dwarf) hamster, also called rat hamster Species...
produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinesehamsterovarycells (CHO). Alteplase causes the breakdown...
systems are ChineseHamsterovary (CHO) and Human embryonic kidney (HEK) cells. Chinesehamsterovarycell Mouse myeloma lymphoblstoid (e.g. NS0 cell) Fully...
genotype of each individual. In cultured mammalian cells, such as the Chinesehamsterovarycell line, a number of genetic loci are present in a functional...
example, researchers were able to overexpress transporter genes in hamsterovarycells to increase monoclonal antibody yield. Another approach could involve...
under development by Bristol-Myers Squibb. It is made using Chinesehamsterovarycells. As of 2018[update], relatlimab is undergoing Phase II/III trials...
were inserted into Chinesehamsterovarycells via transfection. Transfection involves the insertion of DNA into a eukaryotic cell. Unlike the analogous...
intellectual property in CRISPR with Horizon's expertise in Chinesehamsterovarycells. Perkin-Elmer acquired Horizon Discovery for $383 million (£296...
"Characterization of recombinant human orexin receptor pharmacology in a Chinesehamsterovarycell-line using FLIPR". British Journal of Pharmacology. 128 (1): 1–3...
recombinant DNA technology using an established mammalian cell line (Chinesehamsterovarycells). Tenecteplase is a 527 amino acid glycoprotein developed...
cancer cells (HeLa) and human colon cancer cells (Caco-2) in comparison with quercetin itself. Kojic acid has been shown to protect Chinesehamsterovary cells...
peroxin Pex14p. cDNA cloning by functional complementation on a Chinesehamsterovarycell mutant, characterization, and functional analysis". The Journal...
Gupta R (January 1982). "Podophyllotoxin-resistant mutants of Chinesehamsterovarycells. Alteration in a microtubule-associated protein". The Journal...
1976). "A surface glycoprotein modulating drug permeability in Chinesehamsterovarycell mutants". Biochimica et Biophysica Acta (BBA) - Biomembranes....
biologically active recombinant human alglucosidase alfa produced in ChineseHamsterOvarycells. Myozyme falls under the FDA orphan drug designation and was...
molecular basis of emetine resistance in Chinesehamsterovarycells: alteration in the 40S ribosomal subunit". Cell. 10 (1): 61–6. doi:10.1016/0092-8674(77)90140-4...
intellectual property in CRISPR with Horizon's expertise in Chinesehamsterovarycells. Also in 2020, both Mammoth Biosciences and Sherlock Biosciences...
Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. After...
"Characterization of serine palmitoyltransferase activity in Chinesehamsterovarycells". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism...