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Tenecteplase
Clinical data
Trade names
TNKase
AHFS/Drugs.com
Monograph
License data
EU EMA: by INN
ATC code
B01AD11 (WHO)
Legal status
Legal status
In general: ℞ (Prescription only)
Pharmacokinetic data
Excretion
Liver
Identifiers
IUPAC name
Human tissue plasminogen activator
CAS Number
191588-94-0Y
DrugBank
DB00031Y
ChemSpider
none
UNII
WGD229O42W
KEGG
D02837Y
Chemical and physical data
Formula
C2561H3919N747O781S40
Molar mass
58951.37 g·mol−1
NY (what is this?)(verify)
Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug.
Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.
Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.
The abbreviation TNK is common for referring to tenecteplase, but abbreviating drug names is not best practice in medicine, and in fact "TNK" is one of the examples given on the Institute for Safe Medication Practices do-not-use list.
Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug. Tenecteplase is a tissue plasminogen activator...
include tissue plasminogen activator, reteplase, streptokinase, and tenecteplase. Thrombolysis is not recommended in a number of situations, particularly...
and tenecteplase. Alteplase was the first of these versions to go on the market, and has the same exact structure as tPA. Reteplase and tenecteplase both...
activators (rtPA) Alteplase (Activase or Actilyse) Reteplase (Retavase) Tenecteplase Anistreplase (Eminase) In people who receive thrombolytic therapy delivered...
The initials TNK may refer to: Tenecteplase (TNK) - an enzyme used as a thrombolytic drug TNK-BP Ltd. - a Russian oil company The Japanese animation studio...
clots are rare. Novel alternatives to treat catheter occlusion, such as tenecteplase, reteplase, and recombinant urokinase, offer the advantage of shorter...
metastatic gastric cancer with HER2 receptor site positive. 2000: TNKase (tenecteplase): "Clot-busting" drug to treat acute myocardial infarction. 2003: Xolair...
thrombolytic agents similar in structure to rtPA such as reteplase and tenecteplase have been used. These newer agents boast efficacy at least as well as...
Global Information
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