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General structures of sphingolipids
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature.[1] These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with a terminal hydroxyl group is a ceramide. Other common groups bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids.
^Chun J, Hartung HP (2010). "Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis". Clinical Neuropharmacology. 33 (2): 91–101. doi:10.1097/wnf.0b013e3181cbf825. PMC 2859693. PMID 20061941.
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They...
cleavage products: saposins A, B, C, and D. Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. Each domain of the precursor protein is approximately...
with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important...
ORMDL sphingolipid biosynthesis regulator 1 is a protein that in humans is encoded by the ORMDL1 gene. GRCh38: Ensembl release 89: ENSG00000128699 – Ensembl...
bilayer. Contrary to previous assumptions that ceramides and other sphingolipids found in cell membrane were purely supporting structural elements, ceramide...
sphingosine backbone. Alternatively, this sphingosine-derived lipid (sphingolipid) can be synthesized from scratch (de novo) by the enzymes serine palmitoyl...
formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate...
ORMDL sphingolipid biosynthesis regulator 3 is a protein that in humans is encoded by the ORMDL3 gene. Variants affecting the expression of this gene are...
stress and improved memory. Sphingomyelin Sphingomyelin is a type of sphingolipid, which contains a backbone of sphingoid bases. It can be found in the...
Yusuf Hannun and Lina Obeid, both of whom were established experts in sphingolipid signaling. In 1998, Hannun moved to the Medical University of South Carolina...
Sphingomyelin (SPH, ˌsfɪŋɡoˈmaɪəlɪn) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds...
eight categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived from condensation of ketoacyl...
pressure rather than genetic drift. One cluster of these diseases affects sphingolipid storage, a secondary effect of which is increased growth of axons and...
of the cell membrane and are found in many parts of the body. Sphingolipids: Sphingolipids are mostly found in the cell membrane of neural tissue. Glycolipids:...
damage to the nervous system. KD involves dysfunctional metabolism of sphingolipids and is inherited in an autosomal recessive pattern. The disease is named...
head and nonpolar tails. Unlike phospholipids, sphingolipids have a sphingosine backbone. Sphingolipids exist in eukaryotic cells and are particularly...
(di)isocyanates and xylene prevent the skin bacteria from producing ceramide-sphingolipid family lipids. Early life deficiency in these lipids predictive which...
with the function of an enzyme that processes biomolecules known as sphingolipids, leading to these substances building up in the walls of blood vessels...
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