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Relatlimab information


Relatlimab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetLymphocyte activation gene-3 (LAG-3)
Clinical data
Other namesBMS-986016, relatlimab-rmbw
License data
  • US DailyMed: Relatlimab
Routes of
administration
Intravenous
Drug classAntineoplastic
ATC code
  • None
Legal status
Legal status
  • CA: ℞-only[1]
  • US: ℞-only only in combination with nivolumab[2]
Identifiers
CAS Number
  • 1673516-98-7
DrugBank
  • DB14851
UNII
  • AF75XOF6W3
KEGG
  • D11350
Chemical and physical data
FormulaC6472H9922N1710O2024S38
Molar mass145288.79 g·mol−1

Relatlimab is a monoclonal antibody designed for the treatment of melanoma.[3][4] It is used in combination with nivolumab to treat melanoma.[2][5]

Relatlimab is a Lymphocyte activation gene-3 (LAG-3) inhibitor.[2][5] It is under development by Bristol-Myers Squibb.[2][5] It is made using Chinese hamster ovary cells.[2]

  1. ^ "Notice: Multiple additions to the Prescription Drug List (PDL) [2023-12-22]". Health Canada. 22 December 2023. Retrieved 3 January 2024.
  2. ^ a b c d e "Opdualag- nivolumab and relatlimab-rmbw injection". DailyMed. 18 March 2022. Retrieved 22 March 2022.
  3. ^ Cavagnaro JA, Cosenza ME, eds. (2021). Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals. Boca Raton, Florida: CRC Press. ISBN 978-1-00-047185-4.
  4. ^ Robert C (December 2021). "LAG-3 and PD-1 blockade raises the bar for melanoma". Nature Cancer. 2 (12): 1251–3. doi:10.1038/s43018-021-00276-8. PMID 35121906. S2CID 245407697.
  5. ^ a b c Cite error: The named reference Opdualag PR was invoked but never defined (see the help page).

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