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Emetine information


Emetine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
  • P01AX02 (WHO) QP51AX02 (WHO)
Identifiers
IUPAC name
  • (2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-
    tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-
    dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido
    [2,1-a]isoquinoline
CAS Number
  • 483-18-1 checkY
PubChem CID
  • 10219
ChemSpider
  • 9802 checkY
UNII
  • X8D5EPO80M
KEGG
  • C09421 ☒N
ChEBI
  • CHEBI:4781 checkY
ChEMBL
  • ChEMBL50588 checkY
CompTox Dashboard (EPA)
  • DTXSID5022980 Edit this at Wikidata
ECHA InfoCard100.006.903 Edit this at Wikidata
Chemical and physical data
FormulaC29H40N2O4
Molar mass480.649 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point74 °C (165 °F)
SMILES
  • O(c1cc2c(cc1OC)[C@H](NCC2)C[C@H]5C[C@H]4c3c(cc(OC)c(OC)c3)CCN4C[C@@H]5CC)C
InChI
  • InChI=1S/C29H40N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3/t18-,21-,24+,25-/m0/s1 checkY
  • Key:AUVVAXYIELKVAI-CKBKHPSWSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. It takes its name from its emetic properties.[1]

  1. ^ "NCATS Inxight: Drugs". drugs.ncats.io. Retrieved 2020-01-22.

and 25 Related for: Emetine information

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Emetine

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Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root. It takes its name from its emetic properties...

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Syrup of ipecac

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active ingredients are plant alkaloids, cephaeline, and methyl-cephaeline (emetine). Ipecac was used in cough mixtures as an expectorant or an emetic from...

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Carapichea ipecacuanha

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of safety and efficacy. An example of emetic compound from the roots is emetine. Ipecacuanha is a slow-growing plant, which reduces its commercial appeal...

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Nariman Mehta

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reaction of unsymmetrical diarylethylenes: II. The synthesis of possible emetine intermediates. He had two daughters and a son.[citation needed] Seagram...

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Alkaloid

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(Noscapine) Spirobenzylisoquinolines Fumaricine Ipecacuanha alkaloids Emetine, protoemetine, ipecoside Benzophenanthridines Sanguinarine, oxynitidine...

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Apomorphine

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feelings in his subjects than the stronger and more unpleasant emetic emetine. In the UK, however, the publication of J Y Dent's (who later went on to...

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The Karen Carpenter Story

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Carpenter's life had been floating around after her sudden death from emetine cardiotoxicity due to anorexia nervosa in February 1983. However, it was...

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The Carpenters

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them Karen had died. The autopsy stated that her death was caused by "emetine cardiotoxicity due to or as a consequence of anorexia nervosa." Under the...

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Hedera helix

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falcarinol, didehydrofalcarinol, rutin, caffeic acid, chlorogenic acid, emetine, nicotiflorin, hederasaponin B and hederacoside C. However, only three...

Word Count : 3267

Karen Carpenter

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11, 1983, discounted drug overdose, attributing Carpenter's death to "emetine cardiotoxicity due to or as a consequence of anorexia nervosa." Her blood...

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Cephaeline

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products such as syrup of ipecac. Chemically, it is closely related to emetine. Cephaeline in the form of syrup of ipecac was once commonly recommended...

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Western African Ebola virus epidemic

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ISSN 1560-7917. PMID 25846490. Yang, Shu; Xu, Miao; Lee, Emily M.; et al. (2018). "Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms:...

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ATC code P01

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Glycobiarsol P01AR53 Glycobiarsol, combinations P01AX01 Chiniofon P01AX02 Emetine P01AX04 Phanquinone P01AX05 Mepacrine P01AX06 Atovaquone P01AX07 Trimetrexate...

Word Count : 321

Dehydroemetine

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Dehydroemetine is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure (they differ only in a double...

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Blastocystosis

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British troops in Egypt in 1916 who recovered following treatment with emetine. A 1990 study published in Military Medicine from Lackland AFB in Texas...

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Brequinar

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Yang J, et al. (October 2019). "Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine". Viruses. 11 (10): 964...

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FIASMA

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Desloratadine Dicycloverine Dicyclomine Dilazep Dimebon Doxepin Drofenine Emetine Fendiline Flunarizine Fluoxetine Flupentixol Fluphenazine Fluvoxamine Hydroxyzine...

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Elaeophora schneideri

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sheep. A combination of tartar emetic (antimony potassium tartrate) and emetine hydrochloride healed the skin lesions. For elimination of the nematodes...

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40S ribosomal protein S14

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hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. GRCh38: Ensembl release 89: ENSG00000164587...

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1817 in science

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Pierre-Joseph Pelletier and Joseph Bienaimé Caventou isolate chlorophyll and emetine. Leopold Gmelin begins publication of his Handbuch der theoretischen Chemie...

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Bernard Fantus

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subcarbonate Bismuth subnitrate Caffeine Charcoal Cerium oxalate Chalk Emetine Lactic acid fermentation Ferrous carbonate Arsenic Iron Quinine Strychnine...

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Glaucarubin

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glaucarubin had a relapse rate of 12%, four times the rate of those treated with emetine–bismuth iodide. Being a cytotoxin, glaucarubin is capable of killing cells...

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Micropeptide

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translation is taking place. Translation elongation inhibitors, such as emetine or cycloheximide, may also be used to obtain ribosome footprints which...

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Edward Bright Vedder

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others to the discovery that ascorbic acid is a vitamin. He discovered that emetine, the active ingredient of the ancient emetic ipecacuanha, is an amoebicide...

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Samuel Nunez

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scurvy which appeared in debilitated patients. He employed ipecacuanha (emetine) empirically without knowing that it had a specific action on the amoeba...

Word Count : 2377

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