cysteine-type endopeptidase activity involved in execution phase of apoptosis
cysteine-type endopeptidase activity involved in apoptotic process
Cellular component
cytosol
nucleoplasm
cytoplasm
Biological process
epithelial cell differentiation
proteolysis
apoptotic process
regulation of apoptotic process
execution phase of apoptosis
cellular response to staurosporine
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
839
12368
Ensembl
ENSG00000138794
ENSMUSG00000027997
UniProt
P55212
O08738
RefSeq (mRNA)
NM_001226 NM_032992
NM_009811
RefSeq (protein)
NP_001217 NP_116787
NP_033941
Location (UCSC)
Chr 4: 109.69 – 109.7 Mb
Chr 3: 129.7 – 129.71 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.[5][6]CASP6 orthologs[7] have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-6 has known functions in apoptosis,[8] early immune response[9][10] and neurodegeneration in Huntington's and Alzheimer's disease.[11]
^ abcGRCh38: Ensembl release 89: ENSG00000138794 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027997 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA (Oct 1996). "Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis". Biochem Biophys Res Commun. 225 (3): 983–9. doi:10.1006/bbrc.1996.1282. PMID 8780721.
^Fernandes-Alnemri T, Litwack G, Alnemri ES (Aug 1995). "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family". Cancer Res. 55 (13): 2737–42. PMID 7796396.
^"OrthoMaM phylogenetic marker: CASP6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-20.
^Cohen, Gerald M. (1997-08-15). "Caspases: the executioners of apoptosis". Biochemical Journal. 326 (1): 1–16. doi:10.1042/bj3260001. ISSN 0264-6021. PMC 1218630. PMID 9337844.
^Bartel, Alexander; Göhler, André; Hopf, Verena; Breitbach, Katrin (2017-07-07). "Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines". PLOS ONE. 12 (7): e0180203. Bibcode:2017PLoSO..1280203B. doi:10.1371/journal.pone.0180203. ISSN 1932-6203. PMC 5501493. PMID 28686630.
^Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Hoshino, Yoshihiko; Segal, Leopoldo N.; Fujita, Yoko; Rom, William N.; Weiden, Michael D. (2011-01-01). "Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M". The Journal of Immunology. 186 (1): 403–410. doi:10.4049/jimmunol.1001906. ISSN 0022-1767. PMC 3151149. PMID 21098228.
^Graham, Rona K.; Ehrnhoefer, Dagmar E.; Hayden, Michael R. (2011-12-01). "Caspase-6 and neurodegeneration". Trends in Neurosciences. 34 (12): 646–656. doi:10.1016/j.tins.2011.09.001. ISSN 0166-2236. PMID 22018804. S2CID 1603684.
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. CASP6 orthologs have been identified in numerous mammals for which complete genome...
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates...
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive...
Activation and assembly of the inflammasome promotes the activation of caspase-1, which then proteolytically cleaves pro-inflammatory cytokines, interleukin...
been found for this gene. DEDD has been shown to interact with: CFLAR, Caspase 8, and FADD. GRCh38: Ensembl release 89: ENSG00000158796 – Ensembl, May...
a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains...
Huntington's disease, including work on the YAC128 HD mouse model, the role of caspase6 in HD, genetic variation in the human HD gene and the potential of allele-specific...
has determined allosteric regulation of caspase-6 selectively by zinc, mutation-based regulation of caspase-7, and lead molecules against heat shock...
heterotetramer enzyme. Active caspase-8 is then released from the DISC into the cytosol, where it cleaves other effector caspases, eventually leading to DNA...
regulation. The activity of HIPK2 is increased through the action of caspase6. Caspase6 cleaves HIPK2 at residue D916 and D977. As a result, the auto-inhibitory...
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. Orthologs of this gene also exist in other mammals, such as sirenians and cetaceans...
Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling...
(December 2003). "Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration". primary. The EMBO Journal. 22 (24): 6537–49...
interactions between FAM117A1 and these other human proteins: Aquaporin-6Caspase6 DPM3 ELOVL4 FATE1 JAGN1 LAMP2 PBX3 SGPL1 SH3GLB1 TMX2 GRCh38: Ensembl...
Inflammasome-dependent pyroptosis involves inflammatory caspases, including caspase-1 and caspase-11 in mice, and caspases-1, -4, and -5 in humans, and is executed by...
the inflammasomes from NLRP1 and 3. Caspase activity that is triggered by the NLRP1 inflammasome activates caspase-6, which destroys the axons of neurons...
DNA-binding of SATB1. This N-terminal region can be cleaved off by caspase-6 and caspase-3 during apoptosis, resulting in dissociation from the chromatin...
TNF-related apoptosis-inducing ligand (TRAIL) activates caspase 3 (CASP3), which in turn interacts with caspases6, 7, 8, 9, and 10 to induce apoptosis in granulosa...
p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6". Cancer Res. 67 (16): 7631–7. doi:10.1158/0008-5472.CAN-07-0334. PMID 17699767...
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