THOC1 information

THOC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WXP
Identifiers
Aliases	THOC1, HPR1, P84, P84N5, THO complex 1
External IDs	OMIM: 606930; MGI: 1919668; HomoloGene: 38012; GeneCards: THOC1; OMA:THOC1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	268,050 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,995,489 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; corpus callosum; ; left ovary; ; left lobe of thyroid gland; ; body of pancreas; ; tibial nerve;
	Top expressed in
	cumulus cell; ; spermatocyte; ; external carotid artery; ; abdominal wall; ; primitive streak; ; spermatid; ; internal carotid artery; ; supraoptic nucleus; ; dermis; ; semi-lunar valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA binding;
Cellular component	cytoplasm; transcription export complex; nuclear matrix; intercellular bridge; THO complex; THO complex part of transcription export complex; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	regulation of DNA recombination; mRNA transport; RNA processing; regulation of transcription, DNA-templated; negative regulation of DNA damage checkpoint; mRNA processing; regulation of DNA-templated transcription, elongation; viral mRNA export from host cell nucleus; transcription, DNA-templated; positive regulation of DNA-templated transcription, elongation; negative regulation of isotype switching to IgA isotypes; RNA splicing; replication fork processing; signal transduction; apoptotic process; RNA export from nucleus; mRNA export from nucleus; mRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	9984
	225160
	ENSG00000079134
	ENSMUSG00000024287
	Q96FV9
	Q8R3N6
	NM_005131
	NM_153552
	NP_005122
	NP_705780
	Wikidata
View/Edit Human	View/Edit Mouse

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.^[5]^[6]

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079134 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024287 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
^ ^a ^b "Entrez Gene: THOC1 THO complex 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079134 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024287 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11979277-5] Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.

[entrez-6] "Entrez Gene: THOC1 THO complex 1".

THOC1 information

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