cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular component
cytoplasm
cytosol
membrane
mitochondrion
nucleus
Biological process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
execution phase of apoptosis
protein processing
human ageing
positive regulation of apoptotic signaling pathway
luteolysis
cellular response to mechanical stimulus
positive regulation of neuron apoptotic process
brain development
intrinsic apoptotic signaling pathway in response to DNA damage
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of apoptotic process
ectopic germ cell programmed cell death
apoptotic signaling pathway
neural retina development
apoptotic process
regulation of apoptotic process
proteolysis
negative regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
835
12366
Ensembl
ENSG00000106144
ENSMUSG00000029863
UniProt
P42575
P29594
RefSeq (mRNA)
NM_032983 NM_001224 NM_032982 NM_032984
NM_007610
RefSeq (protein)
NP_001215 NP_116764 NP_116765
NP_031636
Location (UCSC)
Chr 7: 143.29 – 143.31 Mb
Chr 6: 42.24 – 42.26 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene.[5]CASP2 orthologs[6] have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.
^ abcGRCh38: Ensembl release 89: ENSG00000106144 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029863 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kumar S, White DL, Takai S, Turczynowicz S, Juttner CA, Hughes TP (June 1995). "Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms". Hum. Genet. 95 (6): 641–4. doi:10.1007/bf00209480. PMID 7789948. S2CID 22813779.
^"OrthoMaM phylogenetic marker: CASP2 coding sequence". Archived from the original on 24 September 2015. Retrieved 20 December 2009.
Caspase2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. CASP2 orthologs have been identified in nearly all mammals for...
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
of caspases: initiator caspases (caspases2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive...
length of female fertility in vertebrates, in a mechanism regulated by caspase-2. At Duke she received a Research Mentoring award in 2012 and the Distinguished...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been identified...
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. CASP6 orthologs have been identified in numerous mammals for which complete genome...
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
Through its CARD domain, this protein interacts with, and thus recruits, caspase2/ICH1 to the cell death signal transduction complex that includes tumor...
called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and...
repeat-containing receptors), AIM2 (absent in melanoma 2), IFI16 (IFN-inducible protein 16), and pyrin. Through their caspase activation and recruitment domain (CARD)...
Recently, oocytes were used recently to study the biochemical mechanisms of caspase-2 activation; importantly, this mechanism turns out to be conserved in mammals...
Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates...
because of reduced protein N-terminal acetylation. But in contrast, the caspase-2, which is acetylated by NatA, can interact with the adaptor protein RIP...
complex formed together with the catalytic subunit of DNA-PK (DNA-PKcs)and caspase2. GRCh38: Ensembl release 89: ENSG00000177595 – Ensembl, May 2017 GRCm38:...
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. Orthologs of this gene also exist in other mammals, such as sirenians and cetaceans...
Richard N.; Yuan, Junying; Flavell, Richard A. (2003-01-01). "Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene...
proteases called caspases. It is an inflammatory caspase, along with caspase 1, caspase 4 and the murine caspase 4 homolog caspase 11, and has a role...
Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling...
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