positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of DNA-binding transcription factor activity
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
voluntary musculoskeletal movement
SMAD protein signal transduction
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
adult walking behavior
apoptotic process
adult locomotory behavior
protein phosphorylation
negative regulation of transcription by RNA polymerase II
iris morphogenesis
positive regulation of cell population proliferation
positive regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
positive regulation of JNK cascade
PML body organization
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
regulation of transcription, DNA-templated
embryonic retina morphogenesis in camera-type eye
modulation by virus of host process
retina layer formation
positive regulation of transcription by RNA polymerase II
neuron differentiation
positive regulation of protein binding
cellular response to hypoxia
positive regulation of protein phosphorylation
erythrocyte differentiation
negative regulation of BMP signaling pathway
phosphorylation
regulation of signal transduction by p53 class mediator
transcription by RNA polymerase II
negative regulation of ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
28996
15258
Ensembl
ENSG00000064393
ENSMUSG00000061436
UniProt
Q9H2X6
Q9QZR5
RefSeq (mRNA)
NM_001113239 NM_022740
NM_001136065 NM_001294143 NM_001294144 NM_010433
RefSeq (protein)
NP_001106710 NP_073577
NP_001129537 NP_001281072 NP_001281073 NP_034563
Location (UCSC)
Chr 7: 139.56 – 139.78 Mb
Chr 6: 38.67 – 38.85 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.[5] HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors.[6] It belongs to a family of protein kinases known as the DYRK kinases.[7] Within this family HIPK2 belongs to a group of homeodomain-interacting protein kinases (HIPKs), including HIPK1 and HIPK3.[8] HIPK2 can be found in a wide variety of species and its functions in gene expression and apoptosis are regulated by several different mechanisms.
^ abcGRCh38: Ensembl release 89: ENSG00000064393 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061436 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H (March 2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1518 (1–2): 168–72. doi:10.1016/S0167-4781(00)00308-0. PMID 11267674.
^Sung KS, Go YY, Ahn JH, Kim YH, Kim Y, Choi CY (June 2005). "Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation". FEBS Letters. 579 (14): 3001–8. doi:10.1016/j.febslet.2005.04.053. PMID 15896780. S2CID 37551460.
^Hofmann TG, Mincheva A, Lichter P, Dröge W, Schmitz ML (2000). "Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34". Biochimie. 82 (12): 1123–7. doi:10.1016/S0300-9084(00)01196-2. PMID 11120354.
^Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (October 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". The Journal of Biological Chemistry. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically...
DAXX is then phosphorylated by homeodomain-interacting protein kinase 2 (HIPK2), which then activates apoptosis signal-inducing kinase 1 (ASK1), which...
of a recent study showing that CREB-binding protein is phosphorylated by HIPK2.) In plant physiology, autoradiography can be used to determine sugar accumulation...
or "stress inducible protein" TP53INP1 has been shown to interact with HIPK2 and p53. GRCh38: Ensembl release 89: ENSG00000164938 – Ensembl, May 2017...
has been debated, evidence exists to suggest that c-Abl phosphorylates HIPK2, a serine/threonine kinase, in response to DNA damage and promotes apoptosis...
Y, Schmitz ML, Koseki H, Kitabayashi I (Sep 2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel...
domain of Mdm2 may stimulate its ability to target p53 for degradation. HIPK2 is a protein that regulates Mdm2 in this way. The induction of the p14arf...
found 69 orthologous circRNAs. For example, both humans and mice encode the HIPK2 and HIPK3 genes, two paralogous kinases which produce a large amount of...
signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK". Genes Dev. 18 (7): 816–29. doi:10.1101/gad.1170604. PMC 387421...
Kim Y (2005). "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease...
"The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions". EMBO J. 29 (22): 3750–61. doi:10.1038/emboj...
for activation of PGE of Aire-dependent TRAs. Worth mentioning is also Hipk2, which phosphorylates Aire and CBP however, its absence affects mostly PGE...
(InterPro: IPR003380, IPR023216. SKI protein has been shown to interact with: HIPK2, MECP2, Mothers against decapentaplegic homolog 1 and Mothers against decapentaplegic...
role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles...
Global Information
