cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type peptidase activity
cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular component
NLRP3 inflammasome complex
AIM2 inflammasome complex
IPAF inflammasome complex
endoplasmic reticulum
cytoplasm
Biological process
regulation of apoptotic process
regulation of inflammatory response
proteolysis
execution phase of apoptosis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
100506742
n/a
Ensembl
ENSG00000204403
n/a
UniProt
Q6UXS9
n/a
RefSeq (mRNA)
NM_001191016
n/a
RefSeq (protein)
NP_001177945
n/a
Location (UCSC)
Chr 11: 104.89 – 104.9 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates at C-terminal aspartic acid residues. It is closely related to caspase 1 and other members of the caspase family, known as inflammatory caspases, which process and activate inflammatory cytokines such as interleukin 1 and interleukin 18.
^ abcGRCh38: Ensembl release 89: ENSG00000204403 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Caspase12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates...
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals...
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous...
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires...
more recent example of a disabled gene links the deactivation of the caspase12 gene (through a nonsense mutation) to positive selection in humans. While...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
D. W; Saleh, M (2009). "Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection"...
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation...
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive...
Activation and assembly of the inflammasome promotes the activation of caspase-1, which then proteolytically cleaves pro-inflammatory cytokines, interleukin...
understanding some human diseases. Humans appear to have lost a functional Caspase12 gene, which in other primates codes for an enzyme that may protect against...
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. Orthologs of this gene also exist in other mammals, such as sirenians and cetaceans...
Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been identified...
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. CASP6 orthologs have been identified in numerous mammals for which complete genome...
with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor...
Katayama T, Tohyama M (April 2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated...
the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. In...
and releases the caspases which leads to the activation of caspase 3. This initiator caspase may cause the cleaving of inactive caspase 3, causing it to...
fragmentation factor subunit alpha (DFFA), also known as Inhibitor of caspase-activated DNase (ICAD), is a protein that in humans is encoded by the DFFA...
and celiac disease. Among the inflammatory products of NLRP1 are caspase 1 and caspase 7, which activate the inflammatory cytokine interleukin-1β. Interleukin-1β...
Global Information
