Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti-glaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, idiopathic intracranial hypertension, neurological disorders, or osteoporosis.[1][2][3]
^Supuran CT, Scozzafava A, Conway J, eds. (2004). Carbonic anhydrase: its inhibitors and activators. Boca Raton: CRC Press. ISBN 978-0-415-30673-7.[page needed]
^Supuran, Claudiu T; Scozzafava, Andrea (2000). "Carbonic anhydrase inhibitors and their therapeutic potential". Expert Opinion on Therapeutic Patents. 10 (5): 575–600. doi:10.1517/13543776.10.5.575. S2CID 86519198.
and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonicanhydrases contains a zinc ion. They are...
acetazolamide. Acetazolamide is a carbonicanhydraseinhibitor, hence causing the accumulation of carbonic acid. Carbonicanhydrase is an enzyme found in red...
generation carbonicanhydraseinhibitor, dorzolamide avoids systemic effects associated with first generation carbonicanhydraseinhibitors such as acetazolamide...
Carbonicanhydrase II (gene name CA2) is one of sixteen forms of human α carbonicanhydrases. Carbonicanhydrase catalyzes reversible hydration of carbon...
November 2020. Brinzolamide is a carbonicanhydraseinhibitor (specifically, carbonicanhydrase II). Carbonicanhydrase is found primarily in erythrocytes...
Carbonicanhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonicanhydrase isoforms found in humans...
Sultiame (or sulthiame) is a sulfonamide and inhibitor of the enzyme carbonicanhydrase. It is used as an anticonvulsant. Sultiame was first synthesised...
ethoxyzolamide) is a sulfonamide medication that functions as a carbonicanhydraseinhibitor. It is used in the treatment of glaucoma and duodenal ulcers...
punicalagins for 37 days. In laboratory research, punicalagins had carbonicanhydraseinhibitor activity. Ellagic acid Punicic acid Marzouk, M. S. A.; El-Toumy...
Foundation Calcium–aluminium-rich inclusion, a type of mineral Carbonicanhydraseinhibitor, in pharmacology Codon Adaptation Index, a measure of codon bias...
Carbonicanhydrase 12 is an enzyme that in humans is encoded by the CA12 gene. Carbonicanhydrases (CAs) are a large family of zinc metalloenzymes that...
Myrtales, the two last being Combretaceae. It is a highly active carbonicanhydraseinhibitor. The molecule contains a gallagic acid component linked to a...
(that is, seizure-form activity). It is also known to be a weak carbonicanhydraseinhibitor (similarly to the anticonvulsant topiramate). It is also known...
Methazolamide (trade name Neptazane) is a potent carbonicanhydraseinhibitor. It is indicated in the treatment of increased intraocular pressure (IOP)...
tubular acidosis with failure of H+ secretion Long-term use of a carbonicanhydraseinhibitor such as acetazolamide Other causes Ingestion of ammonium chloride...
found in Platycarya strobilacea. Pedunculagin is a highly active carbonicanhydraseinhibitor in vitro. A total synthesis of pedunculagin has been reported...
Carbonicanhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene. Carbonicanhydrases are a large family of zinc metalloenzymes that catalyze...
is not limited by development of acidosis, as it is with the carbonicanhydraseinhibitors.[citation needed] Additionally, furosemide is a noncompetitive...
common are listed below: As topiramate inhibitscarbonicanhydrase, use with other inhibitors of carbonicanhydrase (e.g. acetazolamide) increases the risk...
ATC code S01 Ophthalmologicals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed...
hypotension. Their use remains controversial. Acetazolamide, a carbonicanhydraseinhibitor, acts as a weak diuretic and modulates CSF production but has...
obese women. Management may include ceasing any known causes, a carbonicanhydraseinhibitor such as acetazolamide, repeated drainage via lumbar puncture...
Combined dRTA and pRTA is also observed as the result of inherited carbonicanhydrase II deficiency. Mutations in the gene encoding this enzyme give rise...
strongly inhibits multiple isoforms of carbonicanhydrase. Some of chlortalidone's diuretic effect is also due to this inhibition of carbonicanhydrase in the...
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