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Methazolamide information


Not to be confused with methimazole, metamizole, or acetazolamide.
Methazolamide
Ball-and-stick model of the methazolamide molecule
Clinical data
Other namesN-(3-Methyl-5-sulfamoyl-3H-1,3,4-thiadiazol-2-ylidene) ethanamide
AHFS/Drugs.comMonograph
MedlinePlusa601233
Routes of
administration		Oral
ATC code
  • S01EC05 (WHO)
Legal status
Legal status
  • US: ℞-only
Pharmacokinetic data
Protein binding~55%
Elimination half-life~14 hours
Identifiers
IUPAC name
  • N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
CAS Number
  • 554-57-4 checkY
PubChem CID
  • 4100
IUPHAR/BPS
  • 6828
DrugBank
  • DB00703 checkY
ChemSpider
  • 3958 checkY
UNII
  • W733B0S9SD
KEGG
  • D00655 ☒N
ChEMBL
  • ChEMBL19 ☒N
CompTox Dashboard (EPA)
  • DTXSID1023281 Edit this at Wikidata
ECHA InfoCard100.008.243 Edit this at Wikidata
Chemical and physical data
FormulaC5H8N4O3S2
Molar mass236.26 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=S(=O)(C\1=N\N(C(=N/C(=O)C)/S/1)C)N
InChI
  • InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4- checkY
  • Key:FLOSMHQXBMRNHR-DAXSKMNVSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery.

This drug has displayed teratogenic effects in rats. Compared to another drug in the same class, acetazolamide, methazolamide requires a lower dose when administered to patients.

and 11 Related for: Methazolamide information

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Methazolamide

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Methazolamide (trade name Neptazane) is a potent carbonic anhydrase inhibitor. It is indicated in the treatment of increased intraocular pressure (IOP)...

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Diuretic

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decreased sodium absorption. Drugs in this class include acetazolamide and methazolamide.[citation needed] These are diuretics which do not promote the secretion...

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Carbonic anhydrase inhibitor

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Arterial blood gases may show a mild hyperchloremic metabolic acidosis. Methazolamide is also a carbonic anhydrase inhibitor. It has a longer elimination...

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List of sulfonamides

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Furosemide Hydrochlorothiazide Indapamide Mefruside Metolazone Xipamide Methazolamide Ethoxzolamide Sultiame Zonisamide Mafenide Amprenavir (HIV protease...

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Anticonvulsant

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Ethosuximide (1955). Phensuximide. Mesuximide. Acetazolamide (1953). Sultiame. Methazolamide. Zonisamide (2000). Lamotrigine (1990). Pheneturide. Phenacemide. Valpromide...

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Dorzolamide

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first generation carbonic anhydrase inhibitors such as acetazolamide, methazolamide, and dichlorphenamide. Dorzolamide lowers intraocular pressure by about...

Word Count : 625

ATC code S01

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S01EC02 Diclofenamide S01EC03 Dorzolamide S01EC04 Brinzolamide S01EC05 Methazolamide S01EC54 Brinzolamide, combinations S01ED01 Timolol S01ED02 Betaxolol...

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List of compounds with carbon number 5

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ethylidenecyclopropane 18631-83-9 C5H8 spiropentane 157-40-4 C5H8N4O3S2 methazolamide 554-57-4 C5H8O cyclobutanecarboxaldehyde 2987-17-9 C5H8O cyclopentanone...

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Severe cutaneous adverse reactions

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various sulfa drugs antibiotic HLA-B*38 SJS, TEN, SJS/TEN ? ? European Methazolamide lowers intraocular pressure HLA-B*59:01 or HLA-CW*01:02 SJS, TEN, SJS/TEN...

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Drug eruption

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HLA-B*38 HLA-B*1502 European, Han SJS, TEN no recommendation available Methazolamide HLA-B*5901 Korean SJS, TEN No Phenytoin HLA-B*1502 Thai, Han SJS, TEN...

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Periodic paralysis

Last Update:

paralyses may include carbonic anhydrase inhibitors (such as acetazolamide, methazolamide or dichlorphenamide), taking supplemental oral potassium chloride and...

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