Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma.[3] It is used as an eye drop.[3] Effects begin within three hours and last for at least eight hours.[3] It is also available as the combination dorzolamide/timolol.[3][4]
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision.[3] Serious side effects include Steven Johnson syndrome.[3] Those allergic to sulfonamides may be allergic to dorzolamide.[3][5] Use is not recommended in pregnancy or breastfeeding.[5] It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humor.[3]
Dorzolamide was approved for medical use in the United States in 1994.[3] It is available as a generic medication.[5] In 2021, it was the 202nd most commonly prescribed medication in the United States, with more than 2million prescriptions.[6][7]
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^"Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
^ abcdefghi"Dorzolamide Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 26 March 2019.
^"Dorzolamide (Ophthalmic Route) Description and Brand Names". Mayo Clinic. Retrieved 3 November 2023.
^ abcBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1148. ISBN 9780857113382.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Dorzolamide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma...
options include carbonic anhydrase inhibitors such as brinzolamide or dorzolamide, a topical sympathomimetic such as apraclonidine or brimonidine tartrate...
acetazolamide and is less associated with adverse effects to the kidney. Dorzolamide is a sulfonamide and topical carbonic anhydrase II inhibitor. It is indicated...
design leading to an approved drug is the carbonic anhydrase inhibitor dorzolamide, which was approved in 1995. Another case study in rational drug design...
carbonic anhydrase inhibitors: timolol and brinzolamide timolol and dorzolamide with α2 agonists: timolol and brimonidine with prostaglandin analogs:...
arguing against such extension between Merck and Hi-tech for the drug dorzolamide (Trusopt). Here too, the first company (Merck) had filed a standard form...
A match against Benevento, testing positive for the banned substance dorzolamide. Although the country's anti-doping prosecutor wanted Rossi to face a...
is used in chronic glaucoma. Carbonic anhydrase inhibitors, such as dorzolamide, brinzolamide, and acetazolamide, lower secretion of aqueous humor by...
Onal S, Gozum N, Gucukoglu A (2005). "Effect of apraclonidine versus dorzolamide on intraocular pressure after phacoemulsification". Ophthalmic Surgery...
Johnson-Pratt LR, DeLucca PT, Polis AB, Kolodny AH, et al. (March 2003). "Dorzolamide/timolol combination versus concomitant administration of brimonidine...
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