Clear, colorless bodily fluid found in the brain and spinal cord
This article uses anatomical terminology.
Cerebrospinal fluid
The cerebrospinal fluid circulates in the subarachnoid space around the brain and spinal cord, and in the ventricles of the brain.
Image showing the location of CSF highlighting the brain's ventricular system
Details
Identifiers
Latin
liquor cerebrospinalis
Acronym(s)
CSF
MeSH
D002555
TA98
A14.1.01.203
TA2
5388
Anatomical terminology
[edit on Wikidata]
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates.
CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. In humans, there is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immunological protection to the brain inside the skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow.
CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside the brain and spinal cord. It fills the ventricles of the brain, cisterns, and sulci, as well as the central canal of the spinal cord. There is also a connection from the subarachnoid space to the bony labyrinth of the inner ear via the perilymphatic duct where the perilymph is continuous with the cerebrospinal fluid. The ependymal cells of the choroid plexus have multiple motile cilia on their apical surfaces that beat to move the CSF through the ventricles.
A sample of CSF can be taken from around the spinal cord via lumbar puncture. This can be used to test the intracranial pressure, as well as indicate diseases including infections of the brain or the surrounding meninges.
Although noted by Hippocrates, it was forgotten for centuries, though later was described in the 18th century by Emanuel Swedenborg. In 1914, Harvey Cushing demonstrated that CSF is secreted by the choroid plexus.
and 28 Related for: Cerebrospinal fluid information
Cerebrospinalfluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is...
A cerebrospinalfluid leak (CSF leak or CSFL) is a medical condition where the cerebrospinalfluid (CSF) that surrounds the brain and spinal cord leaks...
needle is inserted into the spinal canal, most commonly to collect cerebrospinalfluid (CSF) for diagnostic testing. The main reason for a lumbar puncture...
Cerebrospinalfluid rhinorrhoea (CSF rhinorrhoea) refers to the drainage of cerebrospinalfluid through the nose (rhinorrhoea). It is typically caused...
brain. Regions of the choroid plexus produce and secrete most of the cerebrospinalfluid (CSF) of the central nervous system. The choroid plexus consists...
needle is inserted into the spinal canal to collect a sample of cerebrospinalfluid (CSF), can diagnose or exclude meningitis. Some forms of meningitis...
Artificial cerebrospinalfluid (aCSF) is a buffer solution prepared with a composition representative of cerebrospinalfluid that is used experimentally...
Hydrocephalus is a condition in which an accumulation of cerebrospinalfluid (CSF) occurs within the brain. This typically causes increased pressure inside...
ventricle is a region of choroid plexus which produces the circulating cerebrospinalfluid (CSF). The ventricular system is continuous with the central canal...
ventricular system, consisting of four interconnected ventricles in which cerebrospinalfluid is produced and circulated. Underneath the cerebral cortex are several...
Cerebrospinalfluid diversion is a procedure that is used to drain fluid from the brain and spinal cord. A shunt is placed in a ventricle of the brain...
excess fluid away from the brain. They are commonly used to treat hydrocephalus, the swelling of the brain due to excess buildup of cerebrospinalfluid (CSF)...
lymphatic vessels), and small amounts of transcellular fluid such as ocular and cerebrospinalfluids in the "transcellular compartment". The normal processes...
Cerebrospinalfluid (CSF) flow MRI is used to assess pulsatile CSF flow both qualitatively and quantitatively. Time-resolved 2D phase-contrast MRI with...
their EP2 signalling. A study showed that infusing the nourishing cerebrospinalfluid from around brain cells of young mice into aged brains rejuvenates...
These fluids are contained within epithelial lined spaces. Examples of this fluid are cerebrospinalfluid, aqueous humor in the eye, serous fluid in the...
pericardial cavity into which is secreted the pericardial fluid. The fluid is similar to the cerebrospinalfluid of the brain which also serves to cushion and allow...
of cerebrospinalfluid obtained from a lumbar puncture can provide evidence of chronic inflammation in the central nervous system. The cerebrospinal fluid...
to this model, cerebrospinalfluid (CSF) flows into the paravascular space around cerebral arteries, combining with interstitial fluid (ISF) and parenchymal...
pathogenesis of syringomyelia is debated. The cerebrospinalfluid also serves to cushion the brain. Excess cerebrospinalfluid in the central canal of the spinal...
of immunoglobulins that are seen when a patient's blood serum, or cerebrospinalfluid (CSF) is analyzed. They are used in the diagnosis of various neurological...
central nervous system (CNS). It is involved in the production of cerebrospinalfluid (CSF), and is shown to serve as a reservoir for neuroregeneration...
or blood behind the ear drum. A cerebrospinalfluid (CSF) leak occurs in about 20% of cases and may result in fluid leaking from the nose or ear. Meningitis...
meninges are the dura mater, the arachnoid mater, and the pia mater. Cerebrospinalfluid is located in the subarachnoid space between the arachnoid mater...
The key diagnostic test (detection of specific auto-antibodies in cerebrospinalfluid) is not routinely offered by most immunology laboratories. Some of...
relatively minor traumatic event. Another cause can be a reduction in cerebrospinalfluid pressure, which can reduce pressure in the subarachnoid space, pulling...
Global Information
