Furosemide is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease.[4] It has had many trade names including Discoid, Frusemide, Lasix and Uremide. Furosemide may also be used for the treatment of high blood pressure.[4] It can be taken intravenously or orally.[4] When given intravenously, furosemide typically takes effect within five minutes; when taken orally, it typically metabolizes within an hour.[4]
Common side effects include orthostatic hypotension (decrease in blood pressure while standing, and associated lightheadedness), tinnitus (ringing in the ears), and photosensitivity (sensitivity to light).[4] Potentially serious side effects include electrolyte abnormalities, low blood pressure, and hearing loss.[4] It is recommended that serum electrolytes (especially potassium), serum CO2, creatinine, BUN levels, and liver and kidney functioning be monitored in patients taking furosemide. It is also recommended to be alert for the occurrence of any potential blood dyscrasias.[4] Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys.[4] Common side effects of furosemide injection include hypokalemia (low potassium level), hypotension (low blood pressure), and dizziness.[5]
Furosemide was patented in 1959 and approved for medical use in 1964.[6] It is on the World Health Organization's List of Essential Medicines.[7] In the United States, it is available as a generic medication.[4] In 2021, it was the 21st most commonly prescribed medication in the United States, with more than 26million prescriptions.[8][9] In 2020/21 it was the twentieth most prescribed medication in England.[10] It is on the World Anti-Doping Agency's banned drug list due to concerns that it may mask other drugs.[11] It has also been used in race horses for the treatment and prevention of exercise-induced pulmonary hemorrhage.[12][13]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Lasix- furosemide tablet". DailyMed. 26 January 2021. Retrieved 18 November 2022.
^"Furoscix- furosemide injection 80 mg/ 10 ml injection". DailyMed. 21 October 2022. Retrieved 18 November 2022.
^ abcdefghij"Furosemide". The American Society of Health-System Pharmacists. Archived from the original on 19 November 2015. Retrieved 23 October 2015.
^"Coronavirus (COVID-19) Update: December 22, 2020". U.S. Food and Drug Administration (Press release). 22 December 2020. Retrieved 22 December 2020. This article incorporates text from this source, which is in the public domain.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Furosemide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^"PCA England". nhsbsa-opendata.s3.eu-west-2.amazonaws.com. Retrieved 8 August 2022.
^"WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST 2022" (PDF). 2022. p. 12. Archived (PDF) from the original on 10 July 2022. Retrieved 27 July 2022.
^Sullivan S, Hinchcliff K (April 2015). "Update on exercise-induced pulmonary hemorrhage". The Veterinary Clinics of North America. Equine Practice. 31 (1): 187–198. doi:10.1016/j.cveq.2014.11.011. PMID 25770069.
^Hinchcliff KW, Couetil LL, Knight PK, Morley PS, Robinson NE, Sweeney CR, et al. (2015). "Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement". Journal of Veterinary Internal Medicine. 29 (3): 743–758. doi:10.1111/jvim.12593. PMC 4895427. PMID 25996660.
Furosemide is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. It has had many trade names including...
function. The availability of furosemide is highly variable, ranging from 10% to 90%. The biological half-life of furosemide is limited by absorption from...
failure. It is sometimes used to treat high blood pressure. Compared with furosemide, torasemide is associated with a lower risk of rehospitalization for heart...
often synonymous with high-ceiling diuretics. Loop diuretics, such as furosemide, inhibit the body's ability to reabsorb sodium at the ascending loop in...
and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. It is also indicated for...
53 kg category), but was disqualified after being tested positive for furosemide. The following is the list of number of competitors participating in the...
main difference between bumetanide and furosemide is in their bioavailability and potency. About 60% of furosemide is absorbed in the intestine, and there...
positive for furosemide. b Sevdalin Minchev of Bulgaria originally won the bronze medal, but was disqualified after testing positive for furosemide. c Ashot...
given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism from furosemide and absorbed enterically as a reconstituted...
For nonresponders, a loop diuretic may also be added and generally, furosemide is added at a dose of 40 mg/day (max 160 mg/day), or alternatively (bumetanide...
arrest. Causes of hypokalemia include vomiting, diarrhea, medications like furosemide and steroids, dialysis, diabetes insipidus, hyperaldosteronism, hypomagnesemia...
people is also a reason for a medication to be administered IV, as with furosemide. Oral medications also may be less desirable if a person is nauseous or...
intravenous fluids, furosemide, calcitonin, intravenous bisphosphonate, in addition to treating the underlying cause. The evidence for furosemide use, however...
positive for furosemide. 2 Angel Guenchev of Bulgaria originally won the gold medal, but he was disqualified after he tested positive for furosemide. 3 Andor...
(1989-04-01). "Effect of Albumin-Bound Furosemide on the Endocochlear Potential of the Chinchilla: Alleviation of Furosemide-Induced Ototoxicity". Archives of...
kidneys post-ischemia as compared to not having the preconditioning. Furosemide is a common diuretic and is used for the prevention or to reverse acute...
as the thiazide diuretic, bendrofluazide, or a loop diuretic, such as furosemide) is used to control the hyperkalemia. Addison's disease Adrenal gland...
giving oxygen to correct hypoxemia, administering morphine, diuretics like furosemide, addition of an ACE inhibitor, use of nitrates and use of digoxin if indicated...
family of molecules containing these functional groups. Examples include: Furosemide, a loop diuretic Sulfadiazine, an antibiotic Sulfamethoxazole, an antibiotic...
are very high include calcium chloride, intravenous normal saline with furosemide, and hemodialysis. Hypermagnesemia is uncommon. Rates among hospitalized...
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