Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for the treatment of hypertension.[3] It does not cause fatigue as associated with beta-blockers. Due to the adverse drug event of causing hyperkalemia, as seen with most ACE Inhibitors, the medication is usually paired with a diuretic.
Captopril was patented in 1976 and approved for medical use in 1980.[4]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^"List of nationally authorised medicinal products Active substance: captopril" (PDF). ema.europa.eu. European Medicines Agency. 26 November 2020. Archived from the original (PDF) on 31 October 2021.
^Vidt DG, Bravo EL, Fouad FM (January 1982). "Medical intelligence drug therapy: captopril". The New England Journal of Medicine. 306 (4): 214–219. doi:10.1056/nejm198201283060405. PMID 7033784.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 978-3-527-60749-5.
Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension...
The captopril challenge test (CCT) is a non-invasive medical test that measures the change in renin plasma-levels in response to administration of captopril...
The captopril suppression test (CST) is a non-invasive medical test that measures plasma levels of aldosterone. Aldosterone production is suppressed by...
temperature), less soluble in methanol, and virtually insoluble in ethanol. Captopril, the first ACE inhibitor, is a functional and structural analog of a peptide...
Enalapril has a slower onset of action than Captopril but a greater duration of action. However, unlike Captopril, Enalapril does not have a thiol moiety...
developed partly to overcome these limitations of captopril. The thiol functional group of captopril was replaced with a carboxylic acid group, but additional...
pressure. This led to the development of captopril, the first ACE inhibitor. When the adverse effects of captopril became apparent new derivates were designed...
23, 2004) was an Argentine-born American chemist who first synthesized captopril, the first ACE inhibitor that was used to treat heart disease. With his...
as Atenolol or ACE inhibitors like Captopril, can cause certain lymphadenopathies for some individuals. Captopril is an analog to proline and completely...
animals with small amounts of venom, using their blood as the antidote. Captopril emulates the function of the toxin found in Brazilian pit viper (Bothrops...
vascularity of the kidney to be transplanted and with a test dose of captopril to highlight possible renal artery stenosis in the donor's other kidney...
hydrochlorothiazide (a thiazide diuretic), atenolol (a beta-blocker), captopril (an ACE inhibitor), clonidine (a central α2-agonist), diltiazem (a calcium...
of other exogenous sources of sulfhydryl groups such as methionine and captopril may produce a similar interaction.[medical citation needed] Phenylalkylamine...
orally was developed: the first angiotensin converting enzyme inhibitor captopril. [citation needed] It was approved by the FDA for the treatment of hypertension...
conversion of angiotensin I into angiotensin II, a potent vasoconstrictor. captopril enalapril fosinopril lisinopril moexipril perindopril quinapril ramipril...
Auscultation (with stethoscope) - bruit ("rushing" sound) Captopril challenge test Captopril test dose effect on the differential renal function as measured...
furosemide, nonsteroidal anti-inflammatory agents, DPP-4 inhibitors, captopril, penicillamine, and antibiotics. The bullae are formed by an immune reaction...
minutes before metamizole. Oral anticoagulants (blood thinners), lithium, captopril, triamterene and antihypertensives may also interact with metamizole,...
successfully used for this condition are medications doxazosin, carvedilol, captopril, and propranolol hydrochloride. Treatment of coexisting conditions, e...
citation needed] Both captopril and lisinopril are examples of ACE inhibitors. However, lisinopril is dosed once a day, whereas captopril may be dosed 2-3...
Socialista dos Trabalhadores), in Brazil Canadian Society of Transplantation Captopril suppression test Cavernous sinus thrombosis Cell Signaling Technology...
the important clinical interactions of probenecid include those with captopril, indomethacin, ketoprofen, ketorolac, naproxen, cephalosporins, quinolones...
indicated as a treatment for hypertension. The medication metabolizes to captopril and desacetylalacepril. Alacepril is primarily used to treat hypertension...
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