Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as penicillin.[1]
Serum sickness may be diagnosed based on the symptoms, and using a blood test and a urine test. It may be prevented by not using an antitoxin derived from animal serum, and through prophylactic antihistamines or corticosteroids. It usually resolves naturally, but may be treated with corticosteroids, antihistamines, analgesics, and (in severe cases) prednisone. It was first characterized in 1906.
^Brucculeri M, Charlton M, Serur D (2006). "Serum sickness-like reaction associated with cefazolin". BMC Clin Pharmacol. 6: 3. doi:10.1186/1472-6904-6-3. PMC 1397863. PMID 16504095.
Serumsickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often...
It is given by injection. Side effects may be severe. They include serumsickness, shortness of breath, and allergic reactions including anaphylaxis....
urticaria, serumsickness-like reactions with rashes, fever and arthralgia, and anaphylaxis. The frequency and severity of serumsickness-like reactions...
know is derived from experimental models of the Arthus reaction and serumsickness. These models support that Fc receptors play a dominant role in the...
human or other animal, inducing temporary passive immunity. To prevent serumsickness, it is often best to use an antitoxin obtained from the same species...
of the liver are present in 1–10% of HBV-infected people and include serum-sickness–like syndrome, acute necrotizing vasculitis (polyarteritis nodosa),...
during the treatment, some patients develop serumsickness or immune complex glomerulonephritis. Serumsickness arises seven to fourteen days after the therapy...
common diseases involving a type III hypersensitivity reaction are serumsickness, post-streptococcal glomerulonephritis, systemic lupus erythematosus...
colitis. Penicillin can also induce serumsickness or a serumsickness-like reaction in some individuals. Serumsickness is a type III hypersensitivity reaction...
doses of antitoxin. In 1906, Clemens Pirquet and Béla Schick described serumsickness in children receiving large quantities of horse-derived antitoxin. Between...
There is also a potential risk for hypersensitivity reactions, and serumsickness, especially from gamma globulin of non-human origin. Passive immunity...
no better than placebo", and in light of a risk of anaphylaxis and serumsickness, "routine use of the antivenom is therefore not recommended". Before...
it's seen in rheumatoid nodules with similar pathology. Also seen in SerumSickness(Type III hypersensitivity reaction) Robbins and Cotran pathologic basis...
to the treatment. The antivenom can cause an immune reaction called serumsickness. Pain management, tetanus immunization, laboratory evaluation, and medical...
ideation Parkinsonism Restlessness Seizures A condition similar to serumsickness Stevens Johnson syndrome Syncope Twitching Urinary frequency Urinary...
dehydration – Studies by Walder concluded that decompression sickness could be reduced in aviators when the serum surface tension was raised by drinking isotonic saline...
polymerase. Antidouble-stranded DNA autoantibodies are likely to be present in serum.[citation needed] Diseases that are often in the differential include: Eosinophilia...
injection into a vein or muscle. Side effects are common. They include serumsickness and allergic reactions including anaphylaxis. Diphtheria antitoxin is...
horse-derived antitoxin is sometimes avoided for fear of infants developing serumsickness or lasting hypersensitivity to horse-derived proteins. To avoid this...
Schizophrenia No consistent evidence of association with autoimmunity. Serumsickness A hypersensitivity. Spondyloarthropathy No consistent evidence of association...
for tetanus prophylaxis as part of wound management. Serumsickness Injections répétées de serum du cheval chez le lapin, Comptes rendus des séances de...
people generally display an allergic response during infusion, known as serumsickness. In the United States, more than 15,000 domesticated animals are bitten...
Increased risk of secondary infections due to immunosuppressive medication Serumsickness due to anti-thymocyte globulin Tricuspid valve regurgitation Repeated...
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