Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound
kininogen 1
Identifiers
Symbol
KNG1
Alt. symbols
KNG, BDK
NCBI gene
3827
HGNC
6383
OMIM
612358
RefSeq
NM_001102416
UniProt
P01042
Other data
Locus
Chr. 3 q21-qter
Search for
Structures
Swiss-model
Domains
InterPro
Bradykinin
Identifiers
Symbol
Bradykinin
Pfam
PF06753
InterPro
IPR009608
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.
A class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors) increase bradykinin levels by inhibiting its degradation, thereby increasing its blood pressure lowering effect. ACE inhibitors are FDA approved for the treatment of hypertension and heart failure.
Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge)...
minutes to hours. The underlying mechanism typically involves histamine or bradykinin. The version related to histamine is due to an allergic reaction to agents...
enzyme in the bradykinin system, the ACE inhibitor drugs allow for increased levels of bradykinin which would normally be degraded. Bradykinin produces prostaglandin...
Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans. The B2 receptor (B2R) is a G protein-coupled...
The bradykinin receptor family is a group of G-protein coupled receptors whose principal ligand is the protein bradykinin. There are two Bradykinin receptors:...
selective COX-2 inhibitor and also inhibits bradykinin-induced pain responses without blocking bradykinin receptors. It was approved for use in Japan...
Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide...
(type 2), this leads to bradykinin disinhibition and bradykinin mediated activation of bradykinin B1 receptor and bradykinin B2 receptor on endothelial...
activation of bradykinin B2 receptors. Icatibant acts as a bradykinin inhibitor by blocking the binding of native bradykinin to the bradykinin B2 receptor...
use in heart failure on July 7, 2015. Sacubitril increases levels of bradykinin, which is responsible for the edema seen sometimes in patients with the...
angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It has a molecular formula of C53H76N14O12 and has been investigated...
A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin. They are members of the autacoid family. Kinins are peptides...
converted to bradykinin by the aminopeptidase enzyme. It can be a substrate for carboxypeptidase M and N. Kallidin is identical to bradykinin with an additional...
angiotensin II and the inactivation of bradykinin were thought to be mediated by the same enzyme. In 1970, using bradykinin potentiating factor (BPF) provided...
bradykinin produced through Factor XII activation by negatively charged surfaces such as filters. When mechanisms for the degradation of bradykinin are...
and is produced mostly by the liver. It is also a precursor protein for bradykinin. Low-molecular-weight-kininogen (LK) is mainly a precursor protein for...
that proteolytically cleaves high-molecular-weight kininogen to produce bradykinin, which is a vasodilator; it is secreted by the acinar cells of all three...
HK to form cHK, releasing a peptide known as bradykinin (BK). BK and its derivatives bind to bradykinin receptors B1 and B2 to mediate inflammation. Artificial...
Gerais) was a Brazilian physician and physiologist, a co-discoverer of bradykinin. Beraldo graduated in medicine in 1942, having studied at the Federal...
lowering the production of angiotensin II and decreasing the breakdown of bradykinin. The decrease in angiotensin II results in relaxation of arteriole smooth...
zinc-activated enzyme found in plasma. It inactivates proteins such as bradykinin and anaphylatoxins in the blood in order to prevent toxic buildup. Lysine...
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