Follicular hyperplasia (FH) is a type of lymphoid hyperplasia and is classified as a lymphadenopathy, which means a disease of the lymph nodes. It is caused by a stimulation of the B cell compartment and by abnormal cell growth of secondary follicles. This typically occurs in the cortex without disrupting the lymph node capsule.[1] The follicles are pathologically polymorphous, are often contrasting and varying in size and shape.[2] Follicular hyperplasia is distinguished from follicular lymphoma in its polyclonality and lack of bcl-2 protein expression, whereas follicular lymphoma is monoclonal, and expresses bcl-2.[3]
^Weiss, L. M.; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology. 26 (Suppl 1): S88–96. doi:10.1038/modpathol.2012.176. PMID 23281438.
^Drew, Torigan; et al. (2001). "Lymphoid hyperplasia of stomach". American Journal of Roentgenology. 177 (1): 71–75. doi:10.2214/ajr.177.1.1770071. PMID 11418401.
^Sattar, Husain (2016). Fundamentals of Pathology. Chicago. ISBN 9780983224624.{{cite book}}: CS1 maint: location missing publisher (link)
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