CIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator
CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator.[5] Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection.[5] Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000179583 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022504 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abSteimle V, Otten LA, Zufferey M, Mach B (Oct 1993). "Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)". Cell. 75 (1): 135–46. doi:10.1016/S0092-8674(05)80090-X. PMID 8402893. S2CID 30276144.
^Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD (Mar 2011). "MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers". Nature. 471 (7338): 377–81. Bibcode:2011Natur.471..377S. doi:10.1038/nature09754. PMC 3902849. PMID 21368758.
CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible...
class II expression is closely regulated in APCs by CIITA, which is the MHC class II transactivator. CIITA is solely expressed on professional APCs; however...
24% with Komo. The language is also called Opo-Shita, Opo, Opuo, Cita, Ciita, Shita (along with Dana), Shiita, Ansita, Kina, and Kwina. The self-name...
single master regulatory factor known as the class II transactivator (CIITA). CIITA is a non-DNA-binding co-activator whose expression is tightly controlled...
proteins that contain it: NAIP (NLP family apoptosis inhibitor protein), CIITA (that is, C2TA or MHC class II transcription activator), HET-E (incompatibility...
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex...
other proteins the most important are: the MHC Class II transactivator (CIITA), IPAF, BIRC1 etc. The ligands are currently known for NOD1 and NOD2. NOD1...
prevent NK cells attacks due to deletion of HLA. Deletion of the B2M and CIITA genes using the CRISPR/Cas9 system has been reported to suppress the expression...
Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression. Proc Natl Acad Sci U S A...
in TAP1, TAP2, TAPBP, or B2M) MHC class II deficiency (with mutations in CIITA, RFXANK, RFX5, or RFXAP) CD25 deficiency CD27 deficiency STAT5b deficiency...
the general transcription factors TFIIE and TFIIF. Other proteins include CIITA, Brm (chromatin remodeler), NF-κB (p65), TAL1/SCL, Beta2/NeuroD, C/EBPβ...
genes can lead to BLS II. The genes' names are: class II trans-activator (CIITA) regulatory factor of the Xbox 5 (RFX5) RFX-associated protein (RFXAP) RFX...
of only two have been determined. RFX5 has been shown to interact with CIITA. GRCh38: Ensembl release 89: ENSG00000143390 – Ensembl, May 2017 "Human...
class II molecule by direct expression cloning of the transcription factor CIITA". International Immunology. 7 (7): 1087–92. doi:10.1093/intimm/7.7.1087...
domain and has been shown to interact with: Androgen receptor, C-Fos, C-jun, CIITA, CREB-binding protein, Cyclin D1, DDX17, DDX5 and Estrogen receptor alpha...
of multiple myeloma. XPO1 has been shown to interact with: APC, CDKN1B, CIITA, NMD3, Nucleoporin 62, RANBP1, RANBP3, Ran, SMARCB1, and p53. Karyopherin...
histocompatibility class II (MHC II) DRA gene by IFN-gamma. Following induction of the CIITA transcription factor by IFN-gamma, there was recruitment of both CDK7 and...
cells from viruses including COVID-19 and Ebola. They found that one gene, CIITA, can help human cells resist the virus by activating another gene, CD74...
PRRs NOD-like receptors (NLRs) NLRA (A for acidic transactivating domain) CIITA NLRB (B for BIR, or Inhibitor of apoptosis domain) NAIP NLRC (C for CARD...
a family of NLR proteins that includes the transcriptional co-activator CIITA and the canonical inflammasome protein NLRP3. A truncated murine NLRC4 was...
lymphocyte syndrome type II is due to mutations in any of the following genes: CIITA is responsible for giving instructions to create a protein that controls...
Egeland T, Undlien DE (September 2008). "Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency". The Journal...
Mahanta SK, Scholl T, Yang FC, Strominger JL (1997). "Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation...
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